A innovative electrochemiluminescent immunosensor based on carbon nanodots functionalized with poly(amidoamine) dendrimer for α-fetoprotein detection
首发时间:2016-03-07
Abstract:A sandwich-type electrochemiluminescent biosensor based on carbonaceous based nanomaterials was fabricated for alpha-fetoprotein detection. After the capturing antibody was immobilized onto the modified electrode surface, the detection antibody together with poly(amidoamine) dendrimers functionalized carbon nanodots as the recognizable signal tags was self-assembled onto the electrode by typical sandwich immune reaction. Poly(amidoamine) dendrimers functionalized carbon nanodots make the composite not only an immobilizing platform for carrying numerous detection antibodies, but also an promising promoter for the electrochemiluminescent signal of luminol.This immunosensing strategy for alpha-fetoprotein with the assistance of poly(amidoamine) dendrimers functionalized carbon nanodots provided a promising approach in clinical disease scanning.
keywords: electrochemiluminescent biosensor alpha-fetoprotein carbon nanodots poly(amidoamine) dendrimers
点击查看论文中文信息
一种新的基于聚酰胺-胺型树枝状高聚功能化的碳纳米点的电致化学发光免疫传感器用于α-甲胎蛋白检测
摘要:一种基于碳纳米材料的"三明治"夹心型免疫电致化学发光传感器被构建用于检测甲胎蛋白。当捕获抗体被固定到修饰电极表面时,聚酰胺-胺树状聚合物功能化的纳米点修饰的检测抗体作为信号识别标记物,通过经典的夹心免疫反应自主装到电极上。聚酰胺-桉树状聚合物功能化的纳米碳点复合物,不仅可以作为优良的固载平台,还能够显著提高鲁米诺的电致化学发光信号。这种传感策略为甲胎蛋白的临床检测提供了一种简单快捷的方法。
关键词: 电致化学发光 生物传感器 α-甲胎蛋白 碳纳米点 聚酰胺-胺型树枝状高聚物
基金:
论文图表:
引用
No.4679177108716914****
同行评议
勘误表
一种新的基于聚酰胺-胺型树枝状高聚功能化的碳纳米点的电致化学发光免疫传感器用于α-甲胎蛋白检测
评论
全部评论0/1000