发育及DNA损伤反应调节基因1在肿瘤发生发展中的作用机制研究
首发时间:2016-05-24
摘要:发育及DNA损伤反应调节基因1(Regulated in development and DNA damage response 1,REDD1)是近年来发现缺氧诱导因子-1( Hypoxia-induced factor-1,HIF-1)下游重要的靶基因,在多种肿瘤细胞中广泛表达,参与多种肿瘤信号转导通路。本文就REDD1参与影响肿瘤生长、凋亡、自噬和耐药形成等方面的研究进展作一综述。
关键词: 肿瘤 发育及DNA损伤反应调节基因1 凋亡 自噬
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Function of Regulated in development and DNA damage response 1 in cancer and its mechanism
Abstract:Regulated in development and DNA damage response 1(REDD1)was a significant target gene of Hypoxia-induced factor-1(HIF-1). It is widely expressed in multiple kinds of tumor cells and involved in various signal pathways. This article reviews the progress of REDD1 in influencing cancer growth、apoptosis、autophagy and drug resistance.
Keywords: tumor, REDD1, apoptosis, autophagy
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No.4691981115004114****
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发育及DNA损伤反应调节基因1在肿瘤发生发展中的作用机制研究
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