炎症小体在抵抗病毒感染中的作用和机制
首发时间:2016-05-25
摘要:炎症小体是细胞内的一类多蛋白复合物,它可以感知细胞压力、微生物感染和环境中的刺激物,从而诱导caspase1的自我剪切、炎性细胞因子IL-1β和IL-18的成熟与分泌以及细胞炎症和焦亡(pyroptosis)。到目前为止,已确定有多种DNA和RNA病毒可以活化炎症小体,包括NLRP3炎症小体和AIM2炎症小体。炎症小体的活化可以调控机体的固有免疫以及适应性免疫对于病毒感染的清除。本文将从炎症小体在抗病毒免疫过程中的最新进展方面进行综述。
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Function and mechanisms of inflammasomes in anti-virus infections
Abstract:In?ammasome is one kind of cytosolic multiprotein complexes that can sense cellular stress, spacific microbial infection and environmental stimuli, thereby induce the secretion and maturation of IL-1β and IL-18, and then cause the inflammatory responses and cell pyroptosis. By far, there are more and more reports that both DNA and RNA viruses can activate the inflammasomes, including NLRP3 and AIM2 inflammasome. The activation of inflammasomes can control innate and adaptive immune responses against viral infections. Here, we review recent advances of the role of inflammasomes in antiviral immunity.
Keywords: Immunology NLRP3 inflammasome review virus
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