胞内菌活化的炎症小体研究进展
首发时间:2016-05-17
摘要:与胞外菌不同,胞内菌,如结核分枝杆菌、伤寒沙门氏菌、嗜肺军团菌等感染后可长时间在宿主细胞内存活繁殖,造成机体长期的慢性感染。胞内菌分泌的效应蛋白,如鞭毛蛋白、rod蛋白以及其自身病原相关分子模式,如细菌DNA、RNA、脂多糖等都可以强有力活化炎症小体。炎症小体活化后通过诱导炎性细胞因子分泌以及细胞焦亡抵抗胞内细菌感染。本文主要综述了胞内菌活化炎症小体的研究现状。
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The intracellular bacteria induced inflammasome activation
Abstract:In contrast to extracellular bacteria, intracellular bacteria, such as Mycobacterium tuberculosis, Salmonella, Legionella pneumophila can survive and reproduct in the host cell, which lead to long-term chronic infection. Effector proteins, such as flagellin, rod protein secreted by intracellular bacteria and its PAMPs, such as bacterial DNA, RNA, lipopolysaccharide can potently induced inflammasome activation. The activation of inflammasomes induce the secretion of inflammatory cytokines and promote pyroptosis, which against intracellular bacterial infection. Here,we reviewed the research status of intracellular bacteria induced inflammasome activation.
Keywords: immunology intracellular bacteria inflammasome innate immunity
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