Study protocol for non-pharmacological interventions on mild cognitive impairment: A comparison between electroacupuncture and HD-tDCS
首发时间:2016-05-23
Abstract: Background: Mild cognitive impairment (MCI) is an intermediate clinical state between normal aging and dementia. Non-pharmacological interventions like electroacupuncture and transcranial direct current stimulation (tDCS) were demonstrated to be effective treatments for MCI. The proposal aims to compare the interventional effect by electroacupuncture and high definition tDCS (HD-tDCS) on MCI and to investigate and compare the default mode network alterations after the two interventional approaches. Methods: We will conduct a randomized patient- and assessor-blind, intervention-controlled trial to assess the effects differences and similarities between electroacupuncture and HD-tDCS on cognitive ability and brain functional connectivity of older adults with MCI. Sixty older adults meeting Petersen's MCI criteria will be randomly assigned to receive four-week either electroacupuncture or HD-tDCS intervention. Electroacupuncture group will receive electroacupuncture treatments by sterile, single use needle, 1-3 cm depth, 2 Hz with intensity of 5-10 mA. While HD-tDCS group will receive transcranial direct current stimulate with 1.5 mA on left dorsolateral prefrontal cortex (DLPFC). Each intervention lasts 30 minutes, 5 times a week, 20 times in total. All the participants will have pre-test and post test, with neuropsychological assessments and resting-state functional magnetic resonance imaging (fMRI) scan, and a four-month follow-up. Discussion: The results of this study will provide evidences for the intervention effect of electroacupuncture and HD-tDCS for MCI on both cognitive ability and brain functional connectivity. Moreover, the comparisons between these two approaches will also provide evidences for the differences and similarities across different non-pharmacological intervention methods. Trial registration: This trial is registered in the Chinese Clinical Trial Registry (ChiCTR). Registration number: ChiCTR-IOR-15007371. Registration date: 10 November 2015.
keywords: Mild cognitive impairment Electroacupuncture High definition transcranial direct current stimulation Functional magnetic resonance imaging functional connectivity
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非药物改善轻度认知障碍:针刺和高精度经颅直流电刺激的比较研究设计
摘要:研究通过电针和经颅直流电刺激治疗老年人记忆力异常衰退,旨在探索非药物治疗手段在一定周期内持续作用于目标被试的干预效果。研究目标:1) 验证电针和经颅直流电刺激治疗老年人记忆力异常衰退的有效性;2) 比较两种物理治疗方法疗效的差异;3) 通过后续追踪研究探索疗效后效应的保持;4) 在干预前和干预后进行功能磁共振成像数据采集,基于大尺度脑网络理论,通过影像学数据分析探讨治疗对于记忆力衰退老人认知相关网络的改变。5)最后,通过行为学指标和影像学指标的结合,分析行为变化与脑网络改变的特异性、治疗手段的特异性,以及长时程干预之后,后效应保持的特异性。
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No.4686909114610314****
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非药物改善轻度认知障碍:针刺和高精度经颅直流电刺激的比较研究设计
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