高稳定性的L-DNA荧光传感器用于汞离子和银离子的检测
首发时间:2016-06-08
摘要:本文利用手性分子识别机制以及特异性的"T-Hg2+-T"和"C-Ag+-C"结构,构建了一种基于L-DNA的通用型高灵敏荧光传感器,并将其用于汞离子和银离子的检测。L-DNA和D-DNA是对映异构体,其物理和化学性质相似,且对于非手性目标物具有相同的识别能力。利用该特性,本文构建的L-DNA探针实现了对汞离子和银离子等非手性金属离子的高灵敏、高选择性检测。同时L-DNA具有很强的生物稳定性,可以抵抗复杂生物样品中的酶降解,为传感器在实际样品中的应用提供了可能。
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Highly Stable L-DNA Fluorescence Sensor for Mercury(II) and Silver(I) Detection
Abstract:This work reports a sensitive biosensing platorm for the detection of Hg2+ or Ag+ by combining the "T-Hg2+-T" pairs, "C-Ag+-C" pairs with the principle of chiral recognition mechanism. The non-nature L-DNA is the mirror-image enantiomer of nature D-DNA, which has identical physical and chemical properties. Also, L-DNA can specifically recognize the achiral targets with similar sensitivity of traditional D-DNA. Hence, L-DNA probes were constructed to detect achiral molecules Hg2+ and Ag+. This design achieves high selectivity and good sensitivity with extra merits of excellent biostability, which can resist nuclease digestion in complex practical samples. This design provides new insight to construct biostable biosensors.
Keywords: Analytical Chemistry L-DNA Enantiomers Sensor Fluorescence
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