膀胱癌干细胞的生物学特性及研究现状
首发时间:2016-07-08
摘要:膀胱癌(bladder cancer,BC)是我国泌尿系统疾病中最常见的恶性肿瘤。膀胱癌患者经系统化疗后虽然获得了良好的缓解,但治疗后易复发的特性却使膀胱癌的治疗进入了瓶颈。目前已有文献指出膀胱癌组织中包含了一小部分肿瘤干细胞(cancer stem cells,CSCs),当前研究认为肿瘤干细胞是肿瘤发生、发展、复发、转移以及治疗抵抗的根源。因此,本文将从膀胱癌干细胞的起源、标记物和调控通路等生物学特性及潜在的治疗价值等研究现状进行综述,旨在为膀胱癌的治疗及研究寻找突破口。?????
关键词: 外科学 膀胱癌 干细胞 肿瘤发生 标记物 调控通路 治疗
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Biological characteristics and research status of bladder cancer stem cells
Abstract:Bladder cancer(BC) is the most common cancer arising from the urinary system in China. Although several patients can achieve a remission with systemic chemotherapy, the efforts of therapeutic schedule always reached the bottleneck because of the characteristics of reoccurence after treatment. Evidence suggests that BC is contained a small group of cancer stem cells (CSCs) , which may be contribute to tumorigenesis and resistant to various treatments. Therefore, this review examines the present knowledge on bladder CSCs, specifically focus on their proposed origin, markers, regulator pathway and potential therapy based on CSCs theory.
Keywords: ladder cancer cancer stem cells tumorigenesis markers regulator pathway therapy
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No.4699650115678114****
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