家蝇Edin基因的生物信息学分析
首发时间:2016-08-03
摘要:【目的】Edin是一类可由细菌感染诱导产生的小分子多肽,是生物体免疫系统的重要组分。通过转录组水平上家蝇Musca domestica Edin基因家族的筛选及生物信息学分析,为进一步研究家蝇Edin在免疫系统中的功能奠定基础。【方法】基于转录组数据,通过生物信息学方法对家蝇Edin基因进行筛选,并进行系统进化和结构预测分析。【结果】在家蝇转录组中鉴定出10个Edin基因,生物信息学分析显示了Edin转录组基因在基因组中的位置、方向、是否含有Attacin结构域、理化性质、信号肽存在情况以及内含子、外显子分布等内容。并且将些基因与果蝇进行了比对,比较了它们之间的相似度。在通过与Attacin基因的所建的进化树表明Edin基因虽然包含Attacin结构域,但在进化关系上仍有明显的分隔。【结论】研究分析表明,利用家蝇转录组数据筛选的Edin基因在基因组上成簇分布,该研究结果为进一步研究该家族的功能提供了重要理论基础。
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Bioinformatical analysis of edin in Musca domestica, from its transcriptome database
Abstract:【Aim】Antimicrobial peptides are a result of the organisms category by specific genes encoding small molecule polypeptide, is a important component of the biology immune system. Through the transcriptome level housefly (Musca domestica) antibacterial peptide Edin screening of gene families and bioinformatics analysis, for the further study of housefly defensive element to lay a good foundation in the immune system function.【Methods】Based on the transcriptome data, through bioinformatics methods for housefly Edin gene screening and analysis of system evolution and structure prediction.【Results】In housefly transcription group identified 10 Edin protein genes, the bioinformatics analysis showed the location, direction, introns and exons of Edin. By evolutionary tree we can see the Attacin and Edin have significant dividing line on the evolutionary relationships.【Conclusion】The analysis show that the use of housefly transcriptome data screening of Edin genes in clusters in the genomes of distribution, the results for the further research the function of the family provides an important theoretical basis.
Keywords: Musca domestica Edin bioinformatics transcriptome
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