miR-143基因启动子区多态变异与中国人群宫颈癌高发病风险显著相关

王适之; 金华

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miR-143基因启动子区多态变异与中国人群宫颈癌高发病风险显著相关

首发时间：2016-08-11

王适之 ¹
王适之（1985-），男，讲师，主要研究方向：肿瘤流行病学
金华 ²

1、东南大学公共卫生学院，南京 210009
2、南通市肿瘤医院中心实验室，南通 226361

摘要：目的：筛选miR-143基因启动子区可能影响其表达的多态变异（SNPs），研究其与宫颈癌遗传易感性的关系。方法：以571例宫颈癌患者和657例健康女性（对照组）作为研究对象，用 TaqMan MGB (minor grove binder) 探针对候选的多态位点进行基因分型，分析不同基因型与宫颈癌发生风险的关联性以及基因型-宫颈癌临床表型相关性。结果：SNPs rs726953和rs13177623与宫颈癌高发病风险显著相关。与野生基因型CC相比，rs726953合并突变基因型CT/TT罹患宫颈癌发生风险上升1.71倍（OR =1.71, 95%CI = 1.20-2.43）。与野生基因型GG相比，rs13177623合并突变基因型GA/AA罹患宫颈癌发生风险上升1.38倍（OR =1.38, 95%CI = 1.08-1.78）。结论：miR-143基因启动子区rs726953和rs13177623多态性与宫颈癌发生风险显著关联，可作为宫颈癌遗传易感性的生物标志。

关键词：流行病与卫生统计学宫颈癌 miR-143 多态变异遗传易感性

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The significant association of genetic variants in the promoter of miR-143 with high cervical cancer risk in a Chinese population

Wang Shizhi ¹
王适之（1985-），男，讲师，主要研究方向：肿瘤流行病学
Jin Hua ²

1、School of Public Health, Southeast University, Nanjing 210009
2、Core Laboratory, Nantong Tumor Hospital, Nantong 226361

Abstract：Objective: To screen the single nucleotide polymorphisms (SNPs) in the promoter region of miR-143 gene that may affect its expression, explore their relationship with cervical cancer susceptibility, and assess the availability of using markedly associated polymorphisms as molecular markers for cervical cancer screening, individualized prevention and treatment. Methods: In a case-control study of 571 cases and 657 controls, the candidate SNPs were genotyping using TaqMan MGB (minor grove binder) probe. The association of different genotypes of SNPs with cervical cancer risk and clinical phenotype were analyzed. Results: The SNPs rs726953 and rs13177623 were significantly associated with a high risk of cervical cancer. Compared with the wild genotype CC, the rs726953 CT/TT genotypes were associated with a 1.71-fold increased risk of cervical cancer (OR = 1.71, 95% CI = 1.20-2.43). Likewise, compared with wild genotype GG, the rs13177623 GA/AA genotypes were markedly related to a 1.38-fold increased risk of cervical cancer (OR = 1.38, 95% CI = 1.08-1.78). Conclusions: The rs726953 and rs13177623 polymorphisms locating in the miR-143 gene promoter region were significantly associated with cervical cancer risk, and they can be used as biomarkers of genetic susceptibility to cervical cancer.

Keywords： epidemiology and biostatistics cervical cancer miR-143 genetic variants susceptibility

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王适之，金华. miR-143基因启动子区多态变异与中国人群宫颈癌高发病风险显著相关[EB/OL]. 北京：中国科技论文在线 [2016-08-11]. https://www.paper.edu.cn/releasepaper/content/201608-79.

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论文编号	201608-79
论文题目	miR-143基因启动子区多态变异与中国人群宫颈癌高发病风险显著相关
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