成体神经发生异常与帕金森病研究进展
首发时间:2017-04-24
摘要:帕金森病(Parkinson's disease,PD)是一种中脑黑质多巴胺能神经元变性受损和纹状体多巴胺含量明显减少的神经退行性疾病。PD非运动症状中的嗅觉障碍、焦虑及抑郁等会早发于经典的运动症状,对PD的早期诊治有重要意义。目前研究已表明,PD早发的非运动症状(nonmotor symptoms,NMS)与成体神经发生有着紧密的联系。通过探讨并阐明有效调控内源性成体神经干细胞的增殖分化的调控机制,为PD早期NMS的治疗提供科学依据,以达到功能性修复受损神经元以及治疗NMS的目的。
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The defects in adult neurogenesis are involved in Parkinson's disease
Abstract:Parkinson's disease (PD) is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons in the substantia nigra and significant decease of dopamine levels in the striatum. Non-motor symptoms of PD like anhedonia, depression, anxiety, olfactory deficits, sleep disturbances and cognitive dysfunctionusually occur years or even decades prior to prototypical motor symptoms.Likely increased vulnerability of non-motor symptoms may be expected within regions of cellular plasticity caused by abnormal neurogenesis. Investigations on adult SGZ and OB/SVZ neurogenesis thus may set light on the mechanisms of non-motor symptoms in PD.Clarifying the regulation mechanism of proliferation and differentiation of endogenous adult neural stem cells can provide a scientific basis and reference to the functional repair of damaged neurons, in order to achieve the purpose of treatment of NMS.
Keywords: Pharmacology Parkinson's disease Neuronal stem cell Neurogenesis
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No.4726191119380114****
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