Glutathione-Capped Gold Nanoparticles-Based Photoacoustic Sensor for Label-Free Detection of Lead Ions
首发时间:2017-04-24
Abstract:The photoacoustic signal generated by laser-induced nanobubbles (PA-LINB) proved to be a sensitive tool to monitor aggregation of gold nanoparticles. Here, a simple and label-free photoacoustic method for the rapid detection of Pb2+ in aqueous phase was developed. Due to the high affinity of Pb2+ ions to glutathione, the presence of Pb2+ led to the aggregation of glutathione conjugated gold nanoparticles (GSH-GNPs). Hence, by measuring the variation of the PA-LINB signal after the aggregation of GSH-GNPs, Pb2+ can be quantified. A low detection limit for Pb2+ (42 nM) and a wide linear working range (42 ~ 1000 nM) was achieved. Furthermore, the proposed method showed good selectivity against other metal ions.
keywords: Photoacoustic, Laser-induced nanobubbles, Gold nanoparticles, Aggregation, Pb2+
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基于谷胱甘肽修饰的金纳米颗粒的光声传感器对铅离子的免标记检测
摘要:由激光诱导的纳米气泡(PA-LINB)产生的光声信号已被证明是一种监测金纳米颗粒是否聚集的灵敏工具。 在本文中,我们开发了一种简单且无标记的光声法用于快速检测水相中Pb2+离子。 由于Pb2+离子对谷胱甘肽的亲和力高,所以Pb2+的存在可以引起谷胱甘肽修饰的金纳米颗粒(GSH-GNP)聚集。因此,通过测量GSH-GNP聚集后PA-LINB信号的变化,可以实现Pb2 +的定量检测。该方法得到的线性范围为42?1000 nM,最低检测限为42 nM。此外,该方法亦显示出良好的选择性。
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基于谷胱甘肽修饰的金纳米颗粒的光声传感器对铅离子的免标记检测
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