A targetable acid-responsive micellar system for tumor imaging

• 1、Xiamen University College of Chemistry and Chemical Engineering, Xiamen, 361005

Abstract：Tumor-reporting probes are valuable to guide surgical resection of tumor foci elusive to visual inspection. As tumors display distinct arrays of lectins, we herein report the construction of a panel of glycan-displaying micelles for tumor illumination in mice. These micelles consist of cores of Changsha-red responsive to lysosomal acidity and a corona of poly[styrene-alter-(maleic acid)]glycosylated with different galactosamine. These nanoscale micelles are nonfluorescent extracellularly and become luminescent within acidic lysosomes, enabling optical tracking of tumor endocytosis of the micelles. In vivo screening revealed high-efficiency uptake and fluorescence activation of galactosylate micelles by subcutaneous tumor. Given the robustness and high performance of this system, lectin-targA targetA targetable acid-responsive micellar system for tumor imagingable acid-responsive micellar system for tumor imagingeted responsive micelles are attractive for diagnosis or surgical ablation of tumors.

Keywords： polymer chemistry changsha-red galactosamine tumor imaging