Pathological lesion and the antigenic localization of highly pathogenic avian influenza virus in Sheldrake Ducks
首发时间:2017-05-19
Abstract:In this paper, to determine the pathogenicity and antigen distribution of China early H5N1 highly pathogenic avian influenza virus (HPAIV) A/GS/LN/45/04, the Sheldrake ducks were inoculated via the nostrils. Infected ducks appeared depression, orticollis and nystagmus clinical signs, hematoxylin and eosin (HE) stain found multiple organs showed different degrees of pathological changes. In addition, by Immuno-histochemistry (IHC) stain found that A/GS/LN/45/04 virus could duplicated in multiple organs, especially in brain and pancreas. These results could provide some important theoretical basis for the further study of Chinese AIVs.
keywords: highly pathogenic avian influenza pathology H5N1 Sheldrake ducks
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高致病性禽流感病毒感染鸭的致死性病理学变化研究
摘要:为探究国内高致病性禽流感病毒感染家养水禽致病机制,本实验选取对家鸭具有高致病性的早期毒株A/GS/LN/45/04,并对其感染鸭病理学变化进行研究。研究结果表明,病毒感染鸭临床出现明显的神经症状;剖检可见肝脾肿大,多脏器充血、出血;组织病理学观察发现感染鸭全身各器官均有实质性损伤和炎症反应,免疫组化检查发现感染鸭心脏、肝脏、肾脏、大脑、胰腺以及免疫器官均有病毒抗原分布,并且病毒定位与器官组织损伤部位相一致。通过本实验研究,为我国高致病性禽流感病毒感染水禽的致病机制提供重要实验理论依据。
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No.4733275119888814****
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