Fabrication of PLLA/HAp Composite Microspheres via Biomimetic Mineralization method
首发时间:2017-05-03
Abstract:Hydroxyapatite(HA) is a natural gradient in human bones and has excellent biocompatibility and mechanical strength. The composite PLLA/HAp microspheres can combine the advantages for both PLLA and HAp. PLLA/HAp composite microspheres were fabricated by biomimetic mineralization method via soaking the microspheres with different structures in 1.5 times SBF. The morphology and chemical structure of PLLA/HAp composite microspheres were investigated by SEM, FTIR. The chemical composition and crystal form of HAp were investigated by TEM and XRD .The results shows that HAp nanoparticles have a homogeneous distribution on the microspheres and are polycrystalline structure. The PLLA/HAp composite microspheres would have potential application for bone tissue engineering.
keywords: Bioinorganic chemistry bone tissue engineering Hydroxyapatite (HAp) biomimetic mineralization
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生物矿化法制备聚乳酸/羟基磷灰石复合生物微球
摘要:羟基磷灰石(HA)是自然骨的主要组成部分,具有良好的生物相容性和机械强度,因此将聚乳酸/羟基磷灰石复合微球可以综合聚乳酸和羟基磷灰石两者各自的优点。本文通过生物矿化法将不同结构的微球放入1.5倍模拟体液(SBF)中,得到聚乳酸/羟基磷灰石复合微球。通过扫描电镜、红外光谱分别对聚乳酸/羟基磷灰石复合微球的形貌、化学结构进行了表征。表面HA沉积层的化学组分和晶体结构用透射电镜和XRD进行了表征。结果显示羟基磷灰石离子均匀分散在聚乳酸微球上,并且具有多晶结构。聚乳酸/羟基磷灰石复合微球在骨组织工程材料领域有着潜在的应用。
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No.4727736118067514****
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