间充质干细胞免疫调节作用研究进展
首发时间:2017-05-26
摘要:间充质干细胞是一群具有异质性的前体细胞,存在于多种组织中,在组织损伤时,迁移至受损部位参与组织的损伤修复。近年来,科学家发现在炎症的发生、发展过程中,MSCs迁移至受损组织周围,进而影响炎症周围细胞的生长与代谢及功能的发挥和损伤修复。在这篇综述中,我们主要讨论MSCs的生物学特性及免疫调控作用的机制以及MSCs对炎症微环境免疫状态的影响。这将有希望成为新的临床方法用于炎症相关疾病和免疫性疾病的治疗。
关键词: 免疫病理学 间充质干细胞 免疫抑制 固有免疫 适应性免疫
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Research Advance in Immunomodulatory Function of Mesenchymal Stem Cells
Abstract:Mesenchymal stem cells are a heterogeneous group of progenitor cells that exist in a variety of tissues and migrate to damaged tissues during tissue damage. In recent years, the scientists found in the occurrence and development of inflammation, MSCs migrate to damaged tissue, and thus affect the growth and metabolism of inflammatory cells and damage repair of the tissue. In this review, we mainly discuss the biological characteristics of MSCs and the mechanism of immune regulation and the effect of MSCs on the immune status of inflammatory microenvironment. This will become a new clinical method for the treatment of inflammatory-related diseases and immune diseases.
Keywords: Mesenchymal Stem Cells Immunosuppression Innate Immune System Adaptive Immune System
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