单核李斯特菌免疫反应研究进展
首发时间:2017-05-04
摘要:单核细胞增生李斯特菌是一种革兰氏阳性的胞内寄生菌,能够侵染吞噬以及非吞噬细胞,并引发多种人类疾病。当李斯特菌感染宿主细胞后,会被包裹在吞噬小泡中。吞噬小泡会不断与内体及溶酶体融合形成吞噬溶酶体从而降解李斯特菌。但另一方面,部分李斯特菌会通过李斯特菌溶血素(LLO)以及磷脂酰肌醇特异性磷脂酶C(PI-PLC)裂解吞噬体膜,逃离吞噬泡进入宿主细胞胞质增殖,并向邻近细胞的传播,实现细胞间的感染。尽管固有免疫系统对控制胞内李斯特菌的生长具有重要作用,但机体内李斯特菌的最终清除却依赖于适应性免疫。固有免疫以及适应性免疫相互协调共同完成李斯特菌的清除。
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Research progress on immune responses to Listeria monocytogenes
Abstract:Listeria monocytogenes (L. monocytogenes) is a Gram-positive, intracellular pathogen that can cause severe illness in humans and animals. After entry into host cells, L. monocytogenes get packed by vesicles, which soon fuse with endosomes and lysosomes to become phagosomes to degrade L. monocytogenes. However, some of L. monocytogenes escape from phagosomes by lysing the phagosomal membrane using listeriolysin and PI-PLC, replicate in cytoplasm, and subsequently spread from cell to cell. Although innate immunity plays an important role in controlling L. monocytogenes, the final elimination depends on the adaptive immunity. As a result, innate and adaptive immunity work together to kill L. monocytogenes.
Keywords: Listeria monocytogenes virulence factors innate immunity adaptive immunity
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