MicroRNA在其他类型细胞转分化为神经元中的作用
首发时间:2017-05-13
摘要:细胞转分化指的是一种已分化细胞呈现出另一种已分化细胞特征的过程,不仅是转录因子,microRNA也可以实现细胞的转分化。目前有关的研究主要集中于成纤维细胞和间充质干细胞在microRNA的作用下转分化为神经元,这种作用可以是促进性的,也可以是抑制性的。由于神经损伤产生的胶质疤痕区域被大量星形胶质细胞占据,研究microRNA在星形胶质细胞转分化为神经元中的作用,将为神经损伤的临床治疗带来曙光。
For information in English, please click here
The role of MicroRNA in the differentiation of other cells into neurons
Abstract:Cell transdifferentiation reflects a process in which a differentiated cell exhibits the identity of another differentiated cell, not only transcription factor, but microRNA can achieve this process. The current study focused on the role of microRNAs during differentiation from fibroblasts or mesenchymal stem cells to neurons, this effect can be promoted, or inhibited. Because the glial scar area produced by nerve injury is occupied by a large number of astrocytes, the role of microRNAs in the differentiation of astrocytes into neurons will be the dawn of clinical treatment of nerve injury.
Keywords: Cell Biology MicroRNA Transdifferentiation Neuron
论文图表:
引用
No.4733315119532814****
同行评议
共计0人参与
勘误表
MicroRNA在其他类型细胞转分化为神经元中的作用
评论
全部评论0/1000