Advances in Study on Anti-Aging Mechanism of Metformin

• 1、Stem Cell Research Center, Department of Regenerative Medicine, Tongji University School of Medicine, Shanghai 200092
• 2、Translational Stem Cell Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092

Abstract：In a variety of organisms, aging is the comprehensive, spontaneous decline of functionality, which is mediated by genetic and environmental factors. At present,the researchers generally believe that the caloric restriction is the best experimental technology to explore the extension of biological life, But after lots of experiments confirmed that metformin is not required to caloric restriction, it can also activate similar caloric restriction metabolic and stress signaling pathways,which finally achieve the desired effect.This also suggests that metformin can produce the same effects as caloric restriction, such as the extension of the life cycle, reducing the incidence of many degenerative diseases.The mechanism of metformin is mainly manifested in its ability to reduce plasma insulin levels, reduce IGF-1 signaling, inhibit mTOR and mitochondrial complexes in the electron transport chain 1, reduce endogenous reactive oxygen species, activate AMPK, reduce DNA damage, and it also can inhibit inflammation, promote autophagy, and ultimately achieve the purpose of anti-aging.In addition to these possible mechanisms, it also can be found that metformin changes in the impact of cognitive levels through the intestinal microbial.With the further study, the importance of metformin is also increasing.

Keywords： Cell biology Aging Metformin Mechanism Intestinal microbes