脾益气摄血颗粒治疗免疫性血小板减少症临床疗效观察
首发时间:2017-09-12
摘要:目的:观察健脾益气摄血颗粒改善"脾不统血证(脾气虚)"型免疫性血小板减少症(ITP)患者症状及止血疗效。方法:应用中央随机对照、多中心临床试验方法,将符合病例入选标准的ITP患者按3:3:2分为中药组(健脾益气摄血组)、联合组(健脾益气摄血联合强的松组)、西药组(强的松)。治疗21天,每周访视1次,采集症状与出血等数据,最后进行统计学处理。结果:临床症状疗效中药组(104例)、联合组(103例)在临床证候显效率与有效率明显优于西药组(P<0.05),治疗7天后出血程度较入组时明显减轻(P<0.001),且止血疗效早于西药组。联合组的血小板测定值最终高于中药组(P=0.0074),中药组的血小板均值及增长趋势始终低于其他两组(P<0.05)。结论:健脾益气摄血颗粒在改善"脾不统血"ITP患者的脾(气)虚症状及出血症状上,疗效优于并早于单用强的松;联合用药优势更加明显,并且对强的松可能潜在的副反应有一定的缓解作用。???
关键词: 健脾益气摄血颗粒 脾不统血 免疫性血小板减少症 临床疗效?????
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Clinical efficacyof immune thrombocytopenia treated by JianpiYiqiShexue granules
Abstract:Objective: To observe JianpiYiqiShexuegranules improve immune thrombocytopenia(ITP) patients' symptoms and hemostatic efficacy who caused by spleen failing to control blood (spleen qi deficiency). Method: A central randomized, multicenter clinical trial was applied with the ITP patients on TCM syndrome of "spleen failing to control blood (spleen qi deficiency)". 240 patients are divided 90 cases into JianpiYiqiShexue prescription group (trial group), 90 cases into JianpiYiqiShexue prescription combined with prednisone group (combination group), and 60 cases into prednisone group. The subjects took medicine for 21 days and followed-up once a week, collected data of their clinical symptoms, bleeding, adverse reactions. Andthenanalyzed curative effect.Results: The trial group and the combination group were more effective than the prednisone group in the efficiency of the TCM syndromes(P<0.05), the level of bleeding began to decrease(P<0.001) after 7 days of treatment. The PLT of the combination group was higher than the trialgroup finally(P=0.0074), the trial group had lower growth trends than the other 2 groups(P<0.05). Conclusion: The JianpiYiqiShexuegranules can improve ITP patients' spleen deficiency symptoms and bleeding symptoms who caused by spleen failing to control blood, and its curative effect is better and earlier than prednisone alone, the advantages of drug combination are more obvious, and there are some mitigating effects on the potential side effects of prednisone.????
Keywords: JianpiYiqiShexuegranules spleen failing to control blood immune thrombocytopenia clinical efficacy
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脾益气摄血颗粒治疗免疫性血小板减少症临床疗效观察
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