天麻粉与奶粉联合应用改善睡眠功能研究
首发时间:2017-09-15
摘要:目的:研究天麻粉与奶粉联合改善睡眠功能的作用。方法:以天麻粉、奶粉、天麻粉与奶粉三个不同受试物分别为受试物,KM小鼠为受试对象。将动物分为天麻粉组、奶粉组、天麻与奶粉组和阴性对照组,天麻粉组每天灌胃给予1000mg/kg BW天麻粉,奶粉组每天灌胃给予1670mg/kg BW奶粉,天麻与奶粉组每天灌胃给予1000mg/kg BW天麻粉和1670mg/kg BW奶粉,受试物连续给予30d后,进行直接睡眠作用实验、延长戊巴比妥钠睡眠时间实验、戊巴比妥钠阈下剂量催眠实验及巴比妥钠睡眠潜伏期实验。结果:天麻粉组、奶粉组、天麻与奶粉组对小鼠均无直接睡眠作用;在戊巴比妥钠阈下催眠剂量(33.75mg/kg BW)下三组受试物动物入睡发生率均有增加;在戊巴比妥钠阈剂量(52.50mg/kg BW)下三组受试物动物睡眠时间均显著增加;在巴比妥钠阈剂量(281.25mg/kg BW)下三组受试物动物睡眠潜伏期均有显著缩短。结论:天麻粉与奶粉联合使用对改善睡眠具有协同作用,本研究对天麻保健食品的研发具有一定的参考价值。
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Study on improving sleep function by combined application of Gastrodia powder and milk powder
Abstract:Objective: To study the effect of Gastrodia Powder combined with milk powder on improving sleep function. Method:The three dosages of Gastrodia powder, milk powder, Gastrodia Powder and milk powder were test substance, KM mice were experimental animals. The animals were divided into Tianma, milk, Tianma and milk and control group.The Tianma powder group was given 1000mg/kg BW Tianma powder by oarl administration every day, and the milk powder group was given 1670mg/kg BW milk powder by oarl administration every day. The Gastrodia elata and milk powder group were given 1000mg/kg BW Tianma powder and 1670mg/kg BW milk by oarl administration every day after the test substance was administered continuously 30d, to observe the direct effect of sleep, prolong pentobarbital sleep time experiment,subthreshold dose of sodium pentobarbital hypnotic experiments,sodium pentobarbital sleep latency test. Results: The Gastrodia powder, milk powder group, Gastrodia elata and milk powder group had no direct sleep effect on mice; Under the subthreshold hypnotic dose (33.75mg/kg BW) of pentobarbital sodium, the incidence of sleep in the three groups increased; Under the pentobarbital sodium threshold dose (52.50mg/kg BW), the sleeping time of the three groups increased significantly. Under the threshold dose of pentobarbital sodium (281.25mg/kg BW), the sleep latency of the three groups of animals was significantly shortened. Conclusion: the combined use of Gastrodia powder and milk powder has synergistic effect on improving sleep. This study has certain reference value for the research and development of Gastrodia health food.
Keywords: Gastrodia powder milk powder pentobarbital sodium sleep function
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