基于氧化石墨烯的导电聚合物稳定性和细胞相容性的研究
首发时间:2017-12-08
摘要:(1)神经假体是治疗神经系统疾病的一种新兴技术,目前制约神经假体临床应用的一个主要问题是神经电极长期植入后其性能下降,发作具有良好生物相容性和稳定性的神经电极修饰材料有望解决这一难题。本研究采用电化学沉积的方法,以氧化石墨烯作为掺杂子,合成了一种新型的导电聚合物材料,探讨其作为神经电极修饰材料的可能性。结果显示PEDOT/GO较传统的材料PEDOT/pTS具有更好的电化学稳定性,虽然细胞相容性不及PEDOT/PTS,但较电极的基底材料铂好,可以用作神经电极的涂层材料。
关键词: 生物材料 神经电极 导电聚合物 氧化石墨烯 稳定性 细胞相容性
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The stability and cytocompatibility of graphene oxide based conducting polymer
Abstract:Neural electrical stimulation is a new technology in the treatment of neurologicaldisease. One major problem that affects clinical applications of neural electricalstimulator is the decreased performance of implantable neural electrodes afterlong-term implantation. Development of biocompatible and stable neural electrodecoating materials is expected to solve this problem.In this study, graphene oxide (GO) was used as the dopant to synthesize congducting polymer PEDOT/GO and investigate its potential use as neural electrode coating material. The results showed that PEDOT/GO have better electrochemical stability compared to PEDOT/pTS. Althogh the cytocompatibility of PEDOT/GO was not as good as pTS but it was far better than the platinum, which is the substrate material of neural electrode. So PEDOT/GO can be used as the neural electrode coating material.
Keywords: biomaterial neural electrode conducting polymer graphene oxide stability cytocompatibility
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