多囊卵巢综合征患者血清脂联素水平与颈动脉内膜中层厚度的关系
首发时间:2018-02-08
摘要:目的:探讨多囊卵巢综合征(PCOS)患者血清脂联素水平与颈动脉内膜中层厚度(IMT)的关系。方法:纳入初诊初治的PCOS患者214例,根据IMT的厚度分为为颈动脉正常组(n=114)和颈动脉增厚组(n=100),检测所有患者的血清脂联素水平,比较两组间的血清脂联素水平及其与IMT的相关性。结果:两组患者的年龄和BMI匹配,颈动脉增厚组的血清脂联素水平低于颈动脉正常组(5.1±2.4 vs 7.8±3.1 mg/L, P=0.04),相关分析显示IMT与脂联素的相关性r=0.337,p=0.001。二分类回归分析显示脂联素与经典的AS危险因素,如年龄、血压等共同进入回归方程,P值小于0.05,显示脂联素水平(OR=0.701,95%CI0.55-0.87,P<0.01)对IMT增厚有一定的影响作用。结论:PCOS患者IMT与血清脂联素水平与具有相关性,IMT增厚者的血清脂联素水平低,且脂联素是PCOS患者IMT增厚的独立影响因素之一。
关键词: 妇产科学 多囊卵巢综合征 脂联素 颈动脉内膜中层厚度
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Relationship of serum adiponectin with IMT in patients with PCOS
Abstract:Object: To explore relationship of serum adiponectin levels and medial carotid intima thickness in patients with polycystic ovary syndrome. Methods: the study involved 214 patients with PCOS, who was divided into normal group (n = 114) and thickening group (n = 100), according to the thickness of IMT. All patients were detected serum adiponectin levels and hormone profiles and fasting serum insulin and glucose levels. Comparison of serum adiponectin level and its correlation with IMT between the two groups was carried. Results : Serum adiponectinRelationship of serum adiponectin with carotid intima-media thickness(IMT) in patients with Polycystic ovary syndrome level was lower in thickening group than in normal group (5.12.4 vs 7.83.1 mg/L, P = 0.04), correlation analysis showed that serum adiponectin level was negatively associated with IMT (r = -0.337, P = 0.001). Binary classification regression analysis showed that adiponectin levels was an independent determinant on IMT thickness(OR = 0.701, 95% CI0.55-0.87, P < 0.01). Conclusion: serum adiponectin levels and IMT was correlated in PCOS patient. Serum adiponectin was lower in IMT thickening group and was an independent determinant of IMT.
Keywords: department of Obstetrics and Gynecology Polycystic ovary Syndrome adiponectin carotid intima-media thickness
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多囊卵巢综合征患者血清脂联素水平与颈动脉内膜中层厚度的关系
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