推拿疗法对骨骼肌纤维化家兔肌肉组织病理及血管重塑相关生长因子的影响
首发时间:2018-03-01
摘要:目的:从血管重塑的角度,观察推拿疗法治疗骨骼肌纤维化的活血化瘀作用机制。方法:随机选取造模成功的骨骼肌纤维化家兔24只,随机分为治疗组和模型组各12只;另随机选取同期购进且未造模的大耳白家兔12只,设为空白组。对治疗组家兔予以15min/次/d的推拿治疗,其余两组不予特殊处置;连续治疗10d后,对各组家兔进行取材,观察肌肉组织病理的变化、以及肌肉组织中血小板源性生长因子(PDGF)、血管内皮生长因子(VEGF)、表皮生长因子(EGF)和胰岛素样生长因子1(IGF-1)含量的变化。结果:经推拿治疗后,治疗组家兔肌肉组织病理表现为肌肉纤维排列基本正常、纤维增生和炎症渗出明显改善,与模型组具有明显差异;治疗组家兔肌肉组织中PDGF、VEGF和IGF-1的含量明显增高,与模型组比较均具有显著性差异(P<0.05),但两组EGF的含量比较无显著性差异(P>0.05)。结论:推拿疗法具有改善纤维化骨骼肌组织病理变化的作用,其活血化瘀治疗作用与血管重塑相关生长因子PDGF、VEGF和IGF-1密切相关。
关键词: 按摩推拿学 骨骼肌纤维化 组织病理 血管重塑 生长因子
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The effect of massage therapy on muscle tissue pathology and vascular remodeling related growth factors which were on the skeletal muscle fibrosis rabbits
Abstract:Objective: From the perspective of vascular remodeling, to observe the mechanism of promoting blood circulation to remove blood stasis,which was the massage therapy for skeletal muscle fibrosis. Methods: 24 rabbits were randomly selected to be successful in skeletal muscle fibrosis, and 12 were randomly divided into treatment group and model group. In addition, 12 large white rabbits were randomly selected to be purchased in the same period. Treatment of rabbits in the treatment group was treated with 15min/ time /d, and the other two groups were not treated with special treatment. After 10 days of continuous treatment, to materials of each rabbit, observe the muscle tissue pathological changes, and muscle tissues Platelet-derived growth factor (PDGF), Vascular endothelial growth factor (VEGF), Epidermal growth factor (EGF) and Insulin-like growth factor 1 (IGF-1) changes in the content. Results: After the treatment of massage, the muscle tissue pathology of rabbits in the treatment group were basically normal, and the exudation of inflammation was basically disappeared, which was significantly different from the model group. The contents of PDGF, VEGF and IGF-1 were significantly increased in the muscle tissues of rabbits in the treatment group, with significant differences compared with those in the model group (P<0.05), but there was no significant difference in the content of EGF in the two groups (P>0.05). Conclusion: Massage therapy has the effect of improving the pathological changes of fibrotic skeletal muscle, and its therapeutic effect is closely related to vascular remodeling related growth factor PDGF, VEGF and IGF-1.
Keywords: Science of Chinese massage Skeletal muscle fibrosis Histopathology Vascular remodeling Growth factor
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推拿疗法对骨骼肌纤维化家兔肌肉组织病理及血管重塑相关生长因子的影响
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