Impact of Modified Liang-Fu Granules combined with chemotherapy on advanced gastric cancer in quality of life and immune function

• 1、Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Beijing,100700

Abstract：Objective Modified Liang-Fu Granule (MLFG) is a Chinese medicine formula with claims for the treatment of severe gastric distress. The purpose of this clinical study was to observe the effect of MLFG combined with chemotherapy on quality of life and immune function in patients with advanced gastric cancer. Methods In this prospective randomized controlled clinical trial, all patients were randomly assigned to the treatment arm in which MLFG was provided in addition to chemotherapy, or the control arm in which chemotherapy was provided alone. Both arms were provided with best supportive care. Evaluation points were observed and recorded throughout four cycles of chemotherapy including the control rate of disease, Karnofsky performance status, and immune indicators. Results There were 50 patients included in this trial, with 25 in the treatment arm and 25 in the control arm, 1 patient failed to finish the study in the control arm. We found out that (1)Compared with the control group, the treatment group tended to have a higher control rate of disease but there was no statistical significance, P>0.05. (2) The KPS of patients in the chemotherapy alone group decreased after treatment, and there was significant difference between before and after treatment (P <0.01). There was no significant difference in the KPS before and after the treatment with MLFG combined with the chemotherapy group (P> 0.05).(3) There was no significant difference in CD4 + / CD8 + before and after treatment in the chemotherapy alone group (P> 0.05). The CD4 + / CD8 + ratio of the combined treatment group was significantly higher than that before treatment (P <0.05). There was no significant difference in Foxp3 between the two groups before and after treatment. Foxp3 decreased in the combined treatment group after treatment, but the difference was not statistically significant (P> 0.05). Foxp3 in the combined treatment group was lower than that in the chemotherapy alone group (P <0.05). Conclusion This study indicates that there was no significant difference in disease control rate between the two groups; MLFG with chemotherapy can improve patient quality of life and adjust the immunosuppressive status of advanced gastric cancer patients.

Keywords： advanced gastric cancer Modified Liang-Fu Granules quality of life immune function