离子液体溶解法制备高强度血管用胶原膜材料
首发时间:2018-04-02
摘要:采用离子液体溶解法制备高强度血管用膜材料。以离子液体(1-丁基-3-甲基-咪唑氯盐)溶解胶原蛋白,并进行肝素化修饰得到高强度血管用胶原膜材料。材料力学性能测试结果表明,膜材料具有良好的弹性和抗拉强度。扫描电子显微镜观察结果显示膜材料表面为多孔网状结构。细胞活性实验表明,材料具有明显的促细胞增殖作用。血液相容性测试结果表明,随着肝素含量的增加,肝素化膜材料活化部分凝血活酶时间显著延长,血小板粘附量随着材料内肝素量的增加而降低,说明肝素极大地提高了膜材料的血液相容性。综上所述,离子液体法制备的肝素化胶原膜材料在组织工程领域具有广阔前景。
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Preparation of High Strength Vascular Materials With Ionic Liquid Dissolving Collagen
Abstract:Vascular membrane materials with high strength were prepared through an ionic liquid dissolving method. Ionic liquid (1-Butyl-3-methylimidazolium chloride) was used to dissolve collagen, and then the collagen was modified with heparin to prepare high strength films, which were used as vessel graft. The as-prepared collagen-heparin film had excellent elasticity and tensile strength. SEM observations suggested that the prepared film has a porous structure. Cell viability assay indicated that the film facilitated the cell proliferation. Blood compatibility test showed that with the increase of heparin content, APTT was significantly increased while the number of platelet ashesion on the film decreased. This result indicated that modification of collagen with heparin effectively improved the blood compatibility of the film. In summary, heparin-collagen film prepared by ionic liquid dissolving method have strong potential in the field of tissue engineering.
Keywords: ionic liquid collagen heparin high strength film
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离子液体溶解法制备高强度血管用胶原膜材料
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