柠檬酸生产菌株改造的研究进展
首发时间:2018-05-23
摘要:柠檬酸是产量仅次于酒精的世界第二大发酵化学品,而我国是世界上最大的柠檬酸生产和出口国,提高柠檬酸的发酵效率对加强我国该产业的国际竞争力具有重大意义。提高柠檬酸的生产效率关键在于获得高效的柠檬酸生产菌株,本文总结了近年来各国学者在柠檬酸生产菌株改造方面的研究成果,阐述了包括物理化学诱变和基因工程改造在内的主流改造策略,并进一步展望了在当前系统生物学迅猛发展的背景下,柠檬酸生产菌株研发的新趋势。
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Strain improvement for citric acid production
Abstract:Citric acid is the second largest fermentation chemical in the world. The largest production and exportation of citric acid are in China. It is very important to enhance the fermentation efficiency of citric acid for a dominant position in the globlal competition. It is also the key point to screen highly efficient citric acid producing strain for improving the production efficiency of citric acid. This article summarizes the recent research development for enhancing citric acid producing strains in recent years, including physical and chemical mutagenesis and genetic engineering advances. The main strategies for achieving high yields of citric acid were summarized in this paper. Furthermore, we also prospect the new trends of researches on the further development of citrate producing strains promoted by the current rapid development of systems biology.
Keywords: Citric acid production Genetic engineering Systems biology
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