升血小板胶囊联合糖皮质激素治疗特发性血小板减少性紫癜Meta分析
首发时间:2018-07-20
摘要:目的:系统评价升血小板胶囊联合糖皮质激素治疗特发性血小板减少性紫癜的疗效。方法:在 PubMed、中国生物医学文献数据库(CBM)、中国知网数据库(CNKI)、维普期刊中文数据库(VIP)、万方中文数据库检索升血小板胶囊联合激素治疗 ITP 的随机对照临床试验(randomized controlled clinical trials,RCT)。对符合标准的文献进行质量评价和 Meta 分析。结果:共纳入10个RCT,516例患者,Meta 分析结果显示:升血小板胶囊联合激素在治疗 ITP 的总有效率[RR=1.14,95%Cl,(1.05,1.23),P=0.002]、显效率[RR=1.40,95%Cl,(1.12,1.75),P=0.003]、治疗后血小板计数[MD=24.07,95%Cl,(18.53,29.60),p<0.00001]、复发率[RR=0.46,95%Cl,(0.27,0.77),P=0.003]方面优于单纯激素治疗组。结论:经现有文献的 Meta 分析看出,升血小板胶囊联合激素治疗 ITP 的疗效优于单纯激素治疗组。
关键词: 升血小板胶囊 糖皮质激素 特发性血小板减少性紫癜 Meta 分析
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Meta-analysis of the Effectiveness of Platelet Increasing Capsule Combined with Hormone in Treating Idiopathic Thrombocytopenic Purpura
Abstract:Objective: The Meta-analysis was used to evaluate the efficacy of platelet increasing capsules combined with glucocorticoids in the treatment of idiopathic thrombocytopenic purpura (ITP).Methods: RCT of platelet increasing capsules combined with hormone therapy for ITP were searched in PubMed, CBMd, CNKI,VIP, and Wanfang. Quality assessment and meta-analysis of documents that meet the criteria.Results: A total of 10 RCTs and 516 patients were included. The meta-analysis showed that platelet increasing capsules combined with hormones in the total effective rate [RR=1.14Meta-analysis of the Effectiveness of Platelet Increasing Capsule Combined with Hormone in Treating Idiopathic Thrombocytopenic Purpura,95% Cl ,(1.05, 1.23), P=0.002], the effective rate [RR= 1.40,95% Cl, (1.12, 1.75), P = 0.003], platelet count after treatment [MD = 24.07,95% Cl, (18.53, 29.60), p <0.00001] and recurrence rate [RR = 0.46,95% Cl, (0.27, 0.77) ), P = 0.003] is better than the simple hormone treatment group.Conclusion: Current research shows that the efficacy of platelet increasing capsules combined with hormone therapy for ITP is superior to that of hormone therapy alone.
Keywords: Platelet Increasing Capsules Hormone ITP
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