Meta analysis of the efficacy and safety of compound ZaoFan Pills or combined western medicine in the treatment of blood diseases

• 1、Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine，beijing 100700

Abstract：To evaluate the efficacy and safety of compound zaofan pills or combined western medicine in the treatment of blood diseases.Methods The computer retrieved the seven authoritative databases commonly used in China and the world,and collected data from the establishment of the library to the randomized controlled clinical trials of compound ZaoFan pills or combined western medicine in the treatment of blood diseases in January 2018,and carried out data extraction and quality evaluation,and then the Review Manager 5.3 software was used for Meta analysis.Results Finally,15 qualified clinical studies were included,among which 11 were aplastic anemia,3 were myelodysplasia syndromes,and 1 was immune thrombocytopenia.Meta analysis showed that:①The overall efficacy evaluation showed that the compound ZaoFan pills or combined western medicine was significantly better than the western medicine alone (P<0.00001).②The efficacy of compound ZaoFan pills or combined western medicine in the treatment of Aplastic anemia is better than that of western medicine alone (P<0.00001).③The efficacy of compound ZaoFan pills or combined western medicine in the treatment of myelodysplastic syndrome is better than that of western medicine alone (P=0.002).④Six literatures reported treatment-related adverse reactions, mainly mild gastrointestinal reaction and mild liver function damage, but all of them occurred in the combined drug group,so it could not be determined as the result of compound ZaoFan pills.Conclusion Compound ZaoFan pills or combined western medicine is better than western medicine in the treatment of aplastic anemia and myelodysplastic syndrome.It has good safety.

Keywords： Compound ZaoFan Pills Aplastic Anemia Myelodysplastic Syndromes Meta Analysis