Maternal 25-hydroxyvitamin D levels in relation to offspring atopic diseases.

• 1、Department of Pediatrics, Beijing Jishuitan Hospital, Beijing 100035, China
• 2、Department of Pediatrics, Beijing Jishuitan Hospital,Beijing 100035, China

Abstract：Objective To explore relationships between maternal 25-hydroxyvitamin D and atopic diseases in early childhood . Method: Healthy pregnant women who attended prenatal examination, gestational age≥ 28 weeks and agreed the blood test of 25 (OH)D concentrations in the Outpatient Department of Obstetrics and Gynecology in Beijing Jishuitan Hospital from January to March 2016 were recruited and their full-term healthy newborns were included. We collected information of pregnant women by questionnaires, including basic information, history of allergic diseases. Questionnaires were recorded at 6 months, 12months and 2 year-old on telephone interviews, including delivery mode, gender, birth weight and occurrences of infantile wheezing and allergic rhinitis. SPSS22.0 statistical software was used to analyze the data.Results: 487 infants finished the trail. The median of cord serum 25(OH)D3 concentration was 24.38 ng/ml (10.41-79.16 ng/ml). The overall percentage of vitamin D deficiency (<20ng/ml), insufficiency (20ng/ml-30ng/ml), and sufficiency (≥30ng/ml) were 37.8%, 28.1% and 34.1% respectively. We found that incidences of infantile allergic rhinitis and wheezing in group of vitamin D sufficiency were lower than these in group of vitamin D deficiency and vitamin D insufficiency (P<0.001). But there was no significant difference of incidences of allergic rhinitis or wheezing between vitamin D deficiency group and vitamin D insufficiency group. Conclusion: Low late-pregnancy serum 25(OH)D levels increased risk of parent-reported offspring allergic rhinitis and wheezing in early childhood.In this paper……….. (10 Points, Times New Roman)

Keywords： Vitamin D Late pregnancy Allergic rhinitis Wheeze