Modulation Effect of CGRP in Neuropathic Pain

• 1、College of Life Sciences, Fujian Normal University

Abstract：IAs an endogenous neuropeptide, CGRP is involved in many physiological and pathological processes in the body. Recent studies have found that CGRP plays an important role in the development and maintenance of neuropathic pain. Nociceptive information is transmitted from the periphery to the spinal dorsal horn after nerve injury. Thereby inducing the release of CGRP in the spinal dorsal horn and activating CGRP receptors increase the excitability of spinal dorsal horn cells. Activation of the CGRP receptor coupled with Gαs and Gαq or β-arrestin activates the PKB/AKt signaling pathway and the MAPK cascade reaction, indicating that CGRP participates in the neuropathic pain modulation process. Inhibiting the production of CGRP or preventing it from functioning thereby inhibiting signal transduction of pain information and thus alleviating neuropathic pain. Therefore, the role and status of CGRP in the pathogenesis of neuropathic pain can be explored.

Keywords： CGRP, neuropathic pain, signaling transduction