SOCS3调控奶牛泌乳信号通路的研究进展
首发时间:2018-10-17
摘要:细胞因子信SOCS3调控奶牛泌乳信号通路的研究进展号转导抑制因子3(SOCS3)是一种由细胞因子诱导的细胞因子信号转导的负向调节因子。已有证据表明它能够抑制信号转导和转录激活子5(STAT5)的活化,Janus激酶2-信号转导子和转录激活子5(JAK2-STAT5)信号通路在奶牛乳蛋白转录合成中发挥着巨大的作用,且SOCS3的表达对SREBP基因及脂肪酸的合成具有抑制作用。因此,本文就SOCS3的结构与功能对奶牛泌乳信号通路的影响进行综述,旨在为进一步通过人工干预手段提高牛奶中乳蛋白含量提供建设性意见。
关键词: SOCS3 JAK2-STAT5 乳蛋白转录合成
For information in English, please click here
Advances in SOCS3 regulation of lactation signaling pathway in dairy cows
Abstract:Suppressor of cytokine signaling 3 (SOCS3) is a cytokine-induced negative regulator of cytokine signaling. There is evidence that it inhibits the activation of signal transducers and activators of transcription 5 (STAT5), and the Janus kinase 2-signal transducer and activator of transcription 5 (JAK2-STAT5) signaling pathway plays a role in the transcriptional synthesis of milk proteins in dairy cows. And the expression of SOCS3 has an inhibitory effect on the synthesis of SREBP-1c gene and fatty acids. Therefore, this paper reviews the effects of the structure and function of SOCS3 on the lactation signaling pathway of dairy cows, and aims to provide constructive suggestions for further increasing the milk protein content in milk through manual intervention.
Keywords: SOCS3 JAK2/STAT5 milk protein transcription and synthesis
引用
No.****
动态公开评议
共计0人参与
勘误表
SOCS3调控奶牛泌乳信号通路的研究进展
评论
全部评论0/1000