IL-1家族在机体免疫中的表达
首发时间:2018-10-24
摘要:白介素-1(IL-1)家族与天然炎症和免疫反应密切相关。作为先天免疫的重要组成部分,IL-1在动物机体内发生着重要的作用。IL-1家族具有11种细胞因子,其诱导促炎因子的表达并通过白细胞和内皮细胞上的相互作用来对其蛋白进行表达从而来调节机体的炎症反应。IL-1也可以非特异的诱导炎症细胞并调节T淋巴细胞对此进行应答。但IL-1家族细胞因子均缺乏信号肽,需要一种蛋白将其水解进而使其激活成具有活性的分子。本文将对IL-1家族的成员进行论述,并对IL-1的作用途径进行讨论。
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Expression of IL-1 family in immune system
Abstract:The interleukin-1 (IL-1) family is closely related to natural inflammation and immune response. As an important component of innate immunity, IL-1 plays an important role in animal organisms.The IL-1 family has 11 cytokines that induce the expression of pro-inflammatory factors and express their proteins through interactions between leukocytes and endothelial cells to regulate the body\'s inflammatory response.IL-1 can also respond to non-specific induction of inflammatory cells and regulation of T lymphocytes.However, IL-1 family cytokines lack signal peptides and need a protein to hydrolyze them to activate them into active molecules.In this paper, the members of IL-1 family are discussed, and the role of IL-1 is discussed.
Keywords: host immunity IL-1 immunity inflammation
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