Research progress of peptide durgs discovery
首发时间:2018-11-23
Abstract:Peptides are a kind of active substances composed of amino acids, which play an important role in various progress of life activities, including immune defense, cell proliferation/differentiation, tumor pathological changes and so on. Since the first synthetic bioactive peptide was born in 1953, more than 80 polypeptide drugs have been listed in the global market, including some "blockbuster" drugs with sales of more than $1 billion. A large number of peptide drugs have entered the clinical trial or declaring stage. There are many unique advantages of peptide drugs: remarkable effectivity and specificity, less toxicity, low probability to accumulate in the body tissues and a handful of interaction with other drugs. Thus, more and more peptide drugs are widely used in the prevention, diagnosis and treatment of diabetes, tumors, cardiovascular diseases and hepatitis. This article reviewed the current research progress of peptide drugs, and prospects the great development of peptide drugs in the future.
keywords: Biochemistry and molecular biology Peptide Discovery and Design Clinical Research
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多肽类药物的发现及研究进展
摘要:多肽是一类由多种氨基酸组成的在生物体内发挥重要生理功能的活性物质,在生物的免疫防御、细胞的增殖/分化以及肿瘤病变等等生命活动中多肽都扮演着重要的角色。1953年首个人工合成的活性多肽诞生,标志着多肽类药物的研究进入快速发展阶段。至今,已经有超过80种多肽类药物成功上市销售,其中不乏销售额超过10亿美元的"重磅炸弹"级药物。因其具有高活性、优异的靶点特异性、较低的堆积速率以及较弱的毒性等特点,多肽类药物引起了许多研究人员的兴趣,越来越多的多肽类药物在临床上被广泛用于糖尿病、肿瘤、心血管疾病以及肝炎等疾病的预防、诊断与治疗。本文综述了多肽类药物目前的研究进展,对多肽类药物今后巨大的发展前景进行展望。
关键词: 生物化学及分子生物学 多肽 药物研发及设计 临床研究
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