DDX3Y Computational Catalytic Network Construction and Analysis between Left Brain of Chimpanzee and Human
首发时间:2018-11-14
Abstract:DDX3Y computational catalytic network construction and analysis of human left brain is very useful to identify novel markers and potential targets for the understanding of brain mechanism. By integration of gene regulatory network infer (GRNInfer) and the database for annotation, visualization and integrated discovery (DAVID 2010 version) we identified and constructed significant molecule DDX3Y catalytic network from 15 chimpanzee and 14 human left brain samples in the same GEO Dataset GDS2678. Our result verified DDX3Y catalytic module only in the downstream of chimpanzee left brain (AGL, PDIA2, PPID, RBBP6 activation; ENOSF1, GSTM3, RECQL, RPP14 inhibition) and downstream (DDX19A, ENPP2, RPP14, SPTLC1activation; AGL, ENOSF1, GSTM3, RECQL, HERC2P2, HERC2P3, PCSK6, PDE8A, PDIA2, PPID, RBBP6 inhibition), whereas in the upstream of human left brain (GSTM3, HSD17B6, PCSK6 activation; EGFR, ENOSF1 inhibition) and downstream (AGL, DDX19A, EGFR, HSD17B6 activation; ABCC10, ENPP2, GSTM3, HERC2P3, PCSK6, PDE8A, PDIA2, PPID, RECQL, SPTLC1 inhibition). Importantly, we datamined that DDX3Y catalytic cluster of human left brain is involved in nervous system development, ubl conjugation, response to chemical stimulus, neurogenesis, cell development and cognition, regulation of apoptosis, anatomical structure development, ATPase activity, coupled, endoplasmic reticulum, polysaccharide binding, pyrophosphatase activity, cellular localization, transport and calcium ion binding (only in human left brain terms) without Isomerase and zinc ion binding (only in chimpanzee left brain terms), the condition is vital to central nervous system development and cognition of human left brain. Our result demonstrated that common terms in both chimpanzee and human left brain include phosphoprotein, hydrolase, organelle, metabolic process, nucleic acid binding, metal-binding, acetylation, DNA binding, Golgi apparatus, identical protein binding, homeostatic process, signal transducer activity, membrane, developmental process, glycoprotein, cytoskeletal protein binding, regulation of cellular process and biosynthetic process, and these terms are more relative to development and cognition, therefore we deduced the stronger DDX3Y catalytic network in human left brain consistent with our number computation. It would be necessary of the stronger DDX3Y catalytic function to development and cognition of human left brain.
keywords: DDX3Y computational catalytic network construction and analysis human left brain
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黑猩猩和人类左脑中DDX3Y酶催化计算网络的构建及分析
摘要:黑猩猩和人类左脑中DDX3Y酶催化计算网络的构建及分析,为理解大脑神经生物学机制奠定基础并开辟新途径。本文基于GEO数据集GDS2678,从15只黑猩猩和14个人类左脑样本中确定了DDX3Y作为研究对象,并通过整合基因调控网络推断算法(GRNInfer)和功能注释系统(DAVID 2010版本),构建了黑猩猩和人类左脑中DDX3Y的酶催化网络。我们的研究结果证实在黑猩猩左脑上游DDX3Y酶催化模块(AGL,PDIA2,PPID,RBBP6激活;ENOSF1, GSTM3, RECQL, RPP14抑制)和下游(DDX19A,ENPP2,RPP14,SPTLC1激活;AGL, ENOSF1, GSTM3, RECQL, HERC2P2, HERC2P3, PCSK6, PDE8A, PDIA2, PPID, RBBP6抑制);然而在人类左脑的上游中(GSTM3, HSD17B6, PCSK6激活;EGFR, ENOSF1抑制)和下游中(AGL, DDX19A, EGFR, HSD17B6激活; ABCC10, ENPP2, GSTM3, HERC2P3, PCSK6, PDE8A, PDIA2, PPID, RECQL, SPTLC1抑制)。本章进一步挖掘了黑猩猩和人类左脑的DDX3Y酶催化聚类,结果显示DDX3Y酶催化聚类中人类左脑独有的模块有神经系统发育,UBL结合,化学刺激反应,神经形成,细胞的发育和认知,细胞凋亡调节,解剖结构的发育,ATP酶活性,细胞内质网,多糖结合,焦磷酸酶活性,亚细胞定位,运输和钙离子结合;黑猩猩左脑独有的模块有异构酶和锌离子结合,该种情况下有利于人类左脑的中枢神经系统发育和认知;黑猩猩和人类左脑共有的模块有磷蛋白,水解酶,细胞器,代谢过程,核酸结合,金属结合,乙酰化,DNA结合,高尔基体,相同的蛋白质结合,体内平衡过程,信号转导活性,膜,发育过程,糖蛋白,细胞骨架蛋白结合,细胞过程调节和生物合成过程,这种情况也和认知和发育有关,因此,我们预测在人类左脑中DDX3Y酶催化功能到发育和认知是增强的。
关键词: 生物医学工程 DDX3Y 酶催化计算网络构建与分析 人类左脑
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