A Study of Non-analgesic Drugs to Completely Relieve The Pain of Advanced Malignant Tumors

• 1、San Ya Hai Tang Bay Han Zuliang Medical Clinic

Abstract：Purpose: Application of chemotherapeutic drugs, biological agents and traditional Chinese medicines to observe the efficacy of complete remission the pain in advanced malignant tumors。Method: Sixty-three patients with advanced malignant tumors were randomly divided into 2 groups. Thirty-two patients received chemotherapeutic drugs, biological agent, and traditional Chinese medicines. Thirty-one control patients received only chemotherapeutic drugs, and central analgesic drugs. The total treA Study of Non-analgesic Drugs to Completely Relieve The Pain of Advanced Malignant Tumorsatment period was six weeks and the observation period was four weeks. The case number of reporting total pain relief in the two groups, including the efficacy of pain relief, the rate of pain return after withdrawal, and the incidence of adverse reactions were monitored and recorded during the treatment and observation periods. The results for the two groups were compared by X2 test and the significance cutoff p value was p<=0.05.Results: (1) Both treatment and control groups reported effective analgesic results. Effectiveness between treatment and control groups were 84.37 %( 27/32) vs 83.38 %( 26/31). X2 was 0.0841, p>0.05. There was no significant difference. However, there was a very significant difference between the two groups in the efficacy of total remission of pain: 78.12 %( 25/32) in the treatment group vs 22.58 %( 7/31) in the control group, X2 19.4766, p<0.01. (2) Among the 25 patients who had complete remission of pain, there was a single case of pain rebound during the 4 week observation period, while 5 of the 12 patients\' pain rebounded in the control groups. In all, only 7 patients reported complete remission of pain. (3) The treatment group had no obviously adverse effects except for occasional fever and fatigue symptoms in individual patients, while in the control group all patients presented with varying degrees of constipation, sleepiness, dizziness, nauseous and vomiting. Conclusion: Chemotherapeutic drugs combined with biological agents and traditional Chinese medicines were suitable for the treatment of cancer pain in patients with advanced malignant tumors.

Keywords： Advanced malignant tumor non-analgesic drug completely pain remission pain rebound toxic side effects。