Exploration of solid phase synthesis of polypeptide rotaxane

• 1、School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331

Abstract：Rotaxane is an important mechanical interlocking molecule in supramolecular chemistry. The widespread application of rotaxane in materials science, nanotechnology and biological sciences has attracted more and more attention from scientists. The synthesis of rotaxane is mostly synthesized in the liquid phase. The step of synthesizing the rotaxane by this method is cumbersome, time consuming and subjected to multiple separations and purifications resulting in low yield. At present, there are few research reports on the synthesis of rotaxane on the solid phase. This topic uses the synthesis of rotaxane on the solid phase. The reaction can be carried out in a simple reaction vessel, ie, a solid phase reaction tube, which is easy to operate and easy to purify. Therefore, the synthesis of rotaxane on the solid phase is undoubtedly a novel synthesis method for the synthesis of rotaxane. On the other hand, the axis molecule of this subject is a short peptide formed by amino acids, and the cyclic molecule is an amide macrocycle, both of which have good biocompatibility, so the synthesized rotaxane is expected to be the basic unit for constructing biomaterials.

Keywords： rotaxane solid phase peptide synthesis