程序性细胞坏死的结构生物学进展
首发时间:2019-04-16
摘要:程序性细胞坏死是当细胞凋亡受到抑制时的一种受细胞程序调控的死亡方式,与缺血性损伤、神经退行性疾病有关,主要通过RIP1与RIP3两个蛋白相互作用形成死亡小体,后者进一步激活MLKL蛋白,引发细胞坏死过程。随着近期通过晶体和核磁共振等方法对通路中三个蛋白以及复合物的空间结构解析,程序性细胞坏死过程在蛋白质分子水平得以展现,坏死机制更加清晰,也为药物小分子设计和筛选提供了新的靶点和研究方向。
关键词: 关程序性细胞坏死 结构生物学 激酶结构域 同源结合基序
For information in English, please click here
Structural Biology progress in Necroptosis
Abstract:Necroptosis, known as programmed necrosis, refers to death-receptor-initiated cell death under condition apoptosis is prevented, has been found to related to ischemic brain injury and neurodegenerative diseases. RIP1 associated with RIP3, as necrosome, and then phosphorylates MLKL, which initiate necroptosis. With the development of the structures of the above proteins and their complex, resolved by x-ray and NMR, it helps to further understand the mechanism at atomic level, and may facilitate the design and screening of new drug.
Keywords: Necroptosis Structural Biology Pkinase domain RHIM
引用
No.****
动态公开评议
共计0人参与
勘误表
程序性细胞坏死的结构生物学进展
评论
全部评论0/1000