基于铜催化的亚砜亚胺与芳肼的N-芳基化反应研究
首发时间:2019-05-24
摘要:本文对芳肼脱氮气来实现亚砜亚胺N-芳基化的方法进行了研究,制备出了一系列亚砜亚胺类化合物的N-芳基化产物。作者利用苯基甲基的亚砜亚胺和苯肼盐酸盐作为反应底物,通过对反应所涉及到的因素进行筛选,如催化剂、氧化剂、溶剂和碱,作者筛选出了实现芳肼作为芳基源,亚砜亚胺N-芳基化反应的最优反应条件,在最优的条件下成功制备出了21个亚砜亚胺类N-芳基化产物。
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N-arylation of sulfoximinewith arylhydrazine catalyzed by copper
Abstract:In this paper, the method of denitrifying Nitrogen to realize N-arylation of sulfoximine is studied, and a series of N-arylation products of sulfoximine compounds are prepared. The authors used phenyl sulfoximine and phenylhydrazine hydrochloride as reaction substrates, and screened the factors involved in the reaction, such as catalyst, oxidant, solvent. The optimal reaction conditions for the aryl sulfoxide as the aryl source and the sulfoxide imine N-arylation reaction were successfully prepared. Under the optimal conditions, 21 sulfoximine imine N-arylation products were successfully prepared..
Keywords: sulfoximine aryl hydrazine N-arylation
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基于铜催化的亚砜亚胺与芳肼的N-芳基化反应研究
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