量子点产生活性氧的研究及其毒性分析
首发时间:2019-06-24
摘要:量子点作为近年来新型的光敏剂,在癌细胞治疗方面有着巨大的前景。文献中普遍研究的是二元量子点及其合金化后的三元量子点的毒性机制。目前对于量子点在毒性机制的研究主要集中在重金属离子释放的毒性物质,而对于不同元素组成的量子点产生的活性氧(ROS)研究甚少。本文选取了常用的CdTe与CnInS2/ZnS两种不同元素的量子点作为研究对象,通过对两者进行常规的物理表征和细胞毒性测试,并最终对两种量子点产生的ROS分别进行检测,对不同元素的量子点在毒性机制方面的进行了研究。结果发现,两种量子点都产生了ROS,且三元量子点CnInS2/ZnS的毒性更低。根据不同元素组成的量子点产生ROS的特性,推断量子点在毒性机制上拥有很好的应用前景。
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Study on the production of reactive oxygen species from Quantum Dots and their toxicity Analysis
Abstract:Quantum dots (QDs), as a new photosensitizer in recent years, have great prospects in the treatment of cancer cells. The toxicity mechanism of binary QDs and their alloyed ternary QDs is widely studied in the literature. At present, the research on the toxicity mechanism of QDs mainly focuses on the toxic substances released by heavy metal ions, but little research on reactive oxygen species (ROS) produced by QDs composed of different elements. In this paper, the common QDs of CdTe and CnInS2/ZnS are selected as the research objects, and the ROS scores produced by the two kinds of QDs are finally analyzed by routine physical characterization and cytotoxicity test. The toxicity mechanism of QDs with different elements was studied. The results show that both kinds of quantum dots produce ROS, and the toxicity of ternary QDs CnInS2/ZnS is lower. According to the characteristics of ROS produced by QDs of different elements, it is inferred that QDs have a good application prospect in toxicity mechanism.
Keywords: Quantum Dots(QDs) Surface Modification reactive oxygen species(ROS) Cytotoxicity Test
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