TH upstream-inhibited DCI subnetwork for learning in human left hemisphere|Tonsil via nucleo to cytoplasm poly(A) RNA binding
首发时间:2019-12-31
Abstract:High tyrosine hydroxylase (TH) upstream-inhibited enoyl-CoA delta isomerase 1 (DCI) molecular subnetwork was constructed, including upstream NCK adaptor protein 2 (NCK2), retinoblastoma binding protein 6 (RBBP6), sulfotransferase family 1A member 2 (SULT1A2); downstream chromosome 10 open reading frame 10 (C10orf10), forkhead box N3 (FOXN3_2), poly (rC) binding protein 2 (PCBP2_2) reported relation with learning in human left hemisphere. The common biology process of TH upstream-inhibited DCI subnetwork was identified by DAVID, containing upstream NCK2, upstream RBBP6, upstream SULT1A2, downstream FOXN3_2, downstream PCBP2_2, first-core TH as protein binding; upstream SULT1A2, second-core DCI, first-core TH as small molecule metabolic process; upstream RBBP6, downstream PCBP2_2 as poly(A) RNA binding; downstream PCBP2_2, first-core TH as enzyme binding; The common cellular component of upstream NCK2, upstream RBBP6, downstream PCBP2_2, first-core TH as cytoplasm; upstream NCK2, upstream SULT1A2, downstream PCBP2_2, first-core TH as cytosol; downstream C10orf10, second-core DCI, first-core TH as mitochondrion; downstream FOXN3_2, downstream PCBP2_2, first-core TH as nucleus; upstream RBBP6, downstream PCBP2_2 as nucleoplasm; downstream PCBP2_2, second-core DCI as extracellular exosome; The common tissue distributions as Tonsil_3rd maybe exist the same pattern with human left hemisphere. We propose and mutual positively verify tyrosine hydroxylase (TH) upstream-inhibited enoyl-CoA delta isomerase 1 (DCI) subnetwork for learning in human left hemisphere|Tonsil via nucleo to cytoplasm poly(A) RNA binding.
keywords: biomedical engineering TH upstream-inhibited DCI subnetwork for learning human left hemisphere|Tonsil nucleo to cytoplasm poly(A) RNA binding
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人类左脑|扁桃体中TH上游抑制DCI学习子网通过细胞核到质的聚(A)RNA结合
摘要:本文通过GRNInfer构建了人类左脑中酪氨酸羟化酶(TH)上游抑制烯酰辅酶Aδ异构酶1((DCI)的分子亚网包括上游NCK衔接子蛋白2(NCK2),成视网膜细胞瘤结合蛋白6(RBBP6),磺基转移酶家族1A成员2(SULT1A2); 下游染色体10开放阅读框10(C10orf10),叉头盒N3(FOXN3_2),聚(rC)结合蛋白2(PCBP2_2),这些分子均与学习有关。基于DAVID,确定了TH上游抑制DCI亚网相同的生物过程,包括上游NCK2,上游RBBP6,上游SULT1A2,下游FOXN3_2,下游PCBP2_2,主中心TH的蛋白质结合;上游SULT1A2,次中心DCI,主中心TH的小分子代谢过程; 上游RBBP6,下游PCBP2_2的聚(A)RNA结合; 下游PCBP2_2,主中心TH的酶结合。相应的相同的细胞定位包含上游NCK2,上游RBBP6,下游PCBP2_2,主中心TH的细胞质; 上游NCK2,上游SULT1A2,下游PCBP2_2,主中心TH的胞质溶胶; 下游C10orf10,次中心DCI,主中心TH的线粒体; 下游FOXN3_2,下游PCBP2_2,主中心TH的核; 上游RBBP6,下游PCBP2_2的核质; 下游PCBP2_2,次中心DCI的细胞外泌体。相应的相同的组织分布有扁桃体_3rd可能与人类左脑存在相同的模式。我们提出并相互验证酪氨酸羟化酶(TH)上游抑制烯酰辅酶Aδ异构酶1((DCI)子网在人类左脑|扁桃体中的学习通过细胞核到质的聚(A)RNA结合。
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人类左脑|扁桃体中TH上游抑制DCI学习子网通过细胞核到质的聚(A)RNA结合
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