Urine proteome in children with autism

• 1、Gene Engineering Drug and Biotechnology Beijing Key Laboratory,Beijing Normal University，Beijing,100875

Abstract：Autism is a complex neurological disorder. The purpose of this study is to identify potential biomarkers in urine for the diagnosis of autism. We performed comparative proteomic analysis of aged 3 to 7 years autistic and normal children\'s urine using data-independent acquisition quantitative technology. Compared with normal children, 120 differential proteins were identified in the urine of autistic children, of which 24 proteins have been reported to be associated with autism. These differential proteins are involved in multiple signaling pathways, among which endocannabinoid developing neuron pathway, synaptic long term depression pathways, synaptogenesis signaling pathway and mTOR signaling have been reported to be associated with autism. Moreover, several pathways that may be involved in autism were also enriched, such as Ephrin receptor signaling, CERB signaling in neurons and STAT3 signaling. Our results provide objective indicators for the clinical diagnosis of autism, as well as clues and opportunities for understanding the pathogenesis and early intervention of autism.

Keywords： Autism urine proteome biomarker