TH upstream-inhibited UBR5 subnetwork for learning in human left hemisphere|Prostate via nucleus to cytoplasm protein binding
首发时间:2020-01-03
Abstract:High tyrosine hydroxylase (TH) upstream-inhibited ubiquitin protein ligase E3 component n-recognin 5 (UBR5) molecular subnetwork was constructed, including feedback sulfotransferase family 1A member 2 (SULT1A2); downstream chromosome 10 open reading frame 10 (C10orf10), heterogeneous nuclear ribonucleoprotein H3 (HNRPH3), UPF3 regulator of nonsense transcripts homolog A (yeast) (UPF3A) reported relation with learning in human left hemisphere. The common biology process of TH upstream-inhibited UBR5 subnetwork was identified by DAVID, containing feedback SULT1A2, downstream HNRPH3, downstream UPF3A, second-core UBR5, first-core TH as protein binding; downstream HNRPH3, downstream UPF3A, second-core UBR5 as RNA binding; feedback SULT1A2, first-core TH as small molecule metabolic process; downstream HNRPH3, downstream UPF3A as nucleotide binding; The common cellular component of downstream HNRPH3, downstream UPF3A, second-core UBR5, first-core TH as nucleus; feedback SULT1A2, downstream UPF3A, first-core TH as cytosol; downstream HNRPH3, downstream UPF3A, second-core UBR5 as nucleoplasm; downstream UPF3A, second-core UBR5, first-core TH as cytoplasm; downstream C10orf10, first-core TH as mitochondrion; The common tissue distributions as Prostate_3rd maybe exist the same pattern with human left hemisphere. We propose and mutual positively verify tyrosine hydroxylase (TH) upstream-inhibited ubiquitin protein ligase E3 component n-recognin 5 (UBR5) subnetwork for learning in human left hemisphere|Prostate via nucleus to cytoplasm protein binding.
keywords: TH upstream-inhibited UBR5 subnetwork for learning human left hemisphere|Prostate nucleus to cytoplasm protein binding
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人左脑|前列腺中TH上游抑制UBR5学习子网通过细胞核到质的蛋白结合
摘要:本文通过GRNInfer构建了人类左脑中酪氨酸羟化酶(TH)上游抑制泛素蛋白连接酶E3组分n-识别蛋白5(UBR5)的分子亚网包括反馈磺基转移酶家族1A成员2(SULT1A2); 下游10号染色体开放阅读框10(C10orf10),异质核糖核蛋白H3(HNRPH3),UPF3调节子的无义转录同源物A(酵母)(UPF3A),这些分子均与学习有关。基于DAVID,确定了TH上游抑制UBR5亚网相同的生物过程,包括反馈SULT1A2,下游HNRPH3,下游UPF3A,次中心UBR5,主中心TH的蛋白结合; 下游HNRPH3,下游UPF3A,次中心UBR5的RNA结合; 反馈SULT1A2,主中心TH的小分子代谢过程; 下游HNRPH3,下游UPF3A的核苷酸结合。相应的相同的细胞定位包含下游HNRPH3,下游UPF3A,次中心UBR5,主中心TH的核; 反馈SULT1A2,下游UPF3A,主中心TH的胞质溶胶; 下游HNRPH3,下游UPF3A,次中心UBR5的核质; 下游UPF3A,次中心UBR5,主中心TH的细胞质; 下游C10orf10,主中心TH的线粒体。相应的相同的组织分布有前列腺_3rd可能与人类左脑存在相同的模式。我们提出并相互验证酪氨酸羟化酶(TH)上游抑制泛素蛋白连接酶E3组分n-识别蛋白5(UBR5)子网在人左脑|前列腺中的学习通过细胞核到质的蛋白结合。
关键词: TH上游抑制UBR5学习子网 人左脑|前列腺 细胞核到质 蛋白结合
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人左脑|前列腺中TH上游抑制UBR5学习子网通过细胞核到质的蛋白结合
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