Changes of urine proteome in patients with advanced lung cancer after different drug treatment

• 1、Gene Engineering Drug and Biotechnology Beijing Key Laboratory, Department of Biochemistry and Molecular Biology, College of Life Sciences, Beijing Normal University, Beijing, 100875
• 2、Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing,100730

Abstract：Lung cancer is one of the most threatening diseases to human life and health because of mortality. How to choose more efficient drugs and the appropriate timing of treatment for patients with advanced lung cancer is still a problem. As urine proteome can sensitively reflect the pathological or physiological changes of the body, it has the potential to reflect the dynamic changes of the body after drug treatment. To investigate the changes of the urine proteome of patients with advanced lung cancer after different drug treatment, the urine samples of patients were collected and analyzed at different time points. Compared with pretreatment, the changes of urine proteome were different in each patient，although some of them were treated with same drugs. The changes in the biological process reflected by the differential urinary proteins were consistent with the changes in the clinical manifestations of the patients. This study demonstrates that the pathophysiological changes of patients with advanced lung cancer can be reflected by changes in urinary protein after different drug treatments. In addition, the changes of urinary protein can reflect the different biological processes in patients after the same drug treatment, and the patient\'s clinical condition assessment results are more consistent with these changes. These findings may provide adjuvant information for clinical treatment.

Keywords： Urine Proteome Advanced lung cancer Pathophysiological changes