植物乳杆菌CCFM8610抗幽门螺杆菌的临床效果评价
首发时间:2020-03-23
摘要:本研究拟探究植物乳杆菌CCFM8610抗幽门螺杆菌(Helicobacter pylori, H. pylori)感染的作用效果。研究首先评价了植物乳杆菌CCFM8610体外抑制H. pylori生长和降低其粘附于胃上皮细胞(AGS)的能力,再进一步进行临床效果评价。临床研究招募了39名H. pylori阳性患者,随机分为2组:安慰剂组、植物乳杆菌CCFM8610组,患者服用菌粉一天两次,为期一个月,于治疗前后分别进行一次呼气检测和样本收集工作。结果表明,植物乳杆菌CCFM8610体外抑菌和降低H. pylori粘附的效果显著,且相较于安慰剂组,植物乳杆菌CCFM8610显著降低了临床患者14C呼气值(△UBT 120.38)和胃肠症状评分(p<0.05),同时植物乳杆菌在乳杆菌属中的丰度显著增加,然而患者血清胃蛋白酶原(PG)水平和IL-8、TNF-α免疫因子水平以及肠道菌群无明显变化。这些结果表明植物乳杆菌CCFM8610能够有效的降低患者体内H. pylori定殖量并改善胃肠症状。
关键词: 食品科学 植物乳杆菌 幽门螺杆菌 14C呼气值 胃肠症状评分
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Clinical effect of Lactobacillus plantarum CCFM8610 against Helicobacter pylori infection
Abstract:Based on the potential of Lactobacillus plantarum CCFM8610 against pylori infection, a clinical trial was conducted to evaluate the effect. Firstly, the inhibitory effects on growth of H. pylori and reduction of its adhesion to AGS were evaluated in vitro, and then the clinical effect was further investigated. The clinical study recruited 39 H. pylori-positive patients and were randomly divided into 2 groups: placebo group and Lactobacillus plantarum CCFM8610 group. Probiotic powder was taken twice a day for one month. 14C-Urea breath test (14C-UBT) and sample collection are performed before and after treatment. The in vitro results showed that Lactobacillus plantarum CCFM8610 significantly inhibited the growth of H. pylori as well as reducing the adhesion effect of H. pylori. Compared to placebo group, Lactobacillus plantarum CCFM8610 significantly reduced the level of 14C-UBT (△UBT 120.38) and Gastrointestinal Symptom Rating Scale (GSRS) (p<0.05), at the same time, the abundance of Lactobacillus plantarum CCFM8610 in the Lactobacillus genus increased significantly. However, there was no significant alteration on the level of serum pepsinogen ; IL-8; TNF-α and the intestinal flora. These results suggested that Lactobacillus plantarum CCFM8610 can effectively alleviate H. pylori infection as well as improving GSRS.
Keywords: food science Lactobacillus plantarum H. pylori 14C-UBT GSRS
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