Ameliorative effects of Lactobacillus plantarum CCFM8610 on osteoporosis in ovariectomized rats

• 1、School of Food Science and Technology,Jiangnan University,Wuxi,Jiangsu,214122

Abstract：Postmenopausal osteoporosis, due to its estrogen deficiency, may cause intestinal flora disorder, intestinal barrier damage, intestinal permeability increase and host immunity decrease. At present, most of the drugs used for long-term treatment of osteoporosis have strong side effects, so it is urgent to find a new safe, effective and long-term dietary intervention approach. L.plantarum CCFM8610 has the potential functions of restoring intestinal barrier damage, regulating intestinal immune system and promoting host cell metabolism. The purpose of this study was to investigate the improvement of L.plantarum CCFM8610 on osteoporosis. Methods 24 female SD rats were randomly divided into 4 groups: sham operation group, model control group, positive control group and CCFM8610 group. After 4 weeks of bilateral ovarian excision, the rats continued to intragastate for 30 days. Bone structure indexes, serum cytokines, short-chain fatty acids and intestinal flora were detected. The results showed that L.plantarum CCFM8610 could significantly improve the bone structure index of ovariectomized rats and improve the bone metabolism of ovariectomized rats. In addition, ovariectomized significantly affected the structure and composition of flora, and significantly reduced the content of short-chain fatty acids in the intestinal tract. L.plantarum CCFM8610 showed a certain increase in the number of beneficial bacteria and the content of short-chain fatty acids. Conclusion L.plantarum CCFM8610 plays a good role in the improvement and prevention of osteoporosis in ovariectomized rats, which opens a new path for the prevention and treatment of osteoporosis.

Keywords： Osteoporosis Ovariectomized rats Lactobacillus plantarum CCFM8610 Bone density Inflammatory cytokines