阿魏酸类似物对应激小鼠的氧化还原状态和免疫功能的影响

刘子微; 朱建津; 陈巍文; 李浙烽

0
0
浏览
下载

摘要
关键词
基金信息
论文图表
动态公开评议
相关论文
评论

阿魏酸类似物对应激小鼠的氧化还原状态和免疫功能的影响

首发时间：2020-03-30

刘子微 ¹
刘子微（1994-），女，主要研究方向：食品营养与功能因子
朱建津 ¹
朱建津（1966-），男，副教授、硕导，主要研究方向：食品营养与功能因子
陈巍文 ¹ 李浙烽 ²

1、江南大学食品学院，江苏省无锡市，214122
2、杭州康德权饲料有限公司，浙江杭州，311107

摘要：本文研究了阿魏酸及其类似物姜黄素、谷维素对应激小鼠体内氧化还原状态和免疫功能的影响。方法：将90 只雄性ICR小鼠随机分为6 组，正常组、模型组、阿魏酸组、姜黄素组、谷维素组和阳性对照（辅酶Q10）组。每3 天，正常组肌肉注射生理盐水，其他组注射40 mg/kg体重的强的松进行造模。正常组和模型组饲喂正常饲料，其他四组饲料中分别添加了40 mg/kg的阿魏酸、姜黄素、谷维素和辅酶Q10。饲养8 周后处死取样，测定血浆、肝脏、心脏、肌肉和小肠氧化还原状态和免疫功能相关的指标。结果：(1)造模第九天开始，模型组、阿魏酸组和姜黄素组小鼠日饮水量显著高于正常组（P＜0.05）。(2)阿魏酸、姜黄素、谷维素和辅酶Q10小鼠下丘脑促肾上腺素释放激素(CRH)和垂体促肾上腺皮质激素(ATCH)的含量均显著低于模型组（P＜0.05）；谷维素和辅酶Q10组小鼠血浆皮质酮(CROT)的含量显著低于模型组（P＜0.05）。(3)谷维素组和辅酶Q10组心脏、肝脏和肌肉组织中总抗氧化能力(T-AOC)显著高于模型组（P＜0.05）；谷维素组和辅酶Q10组血浆、肝脏和肌肉组织中总超氧化物歧化酶(SOD)活力显著高于模型组(P＜0.05)；谷维素组和辅酶Q10组血浆和组织里的丙二醛(MDA)含量均显著低于模型组（P＜0.05）。(4)姜黄素组、谷维素组和辅酶Q10组血浆和空肠组织中促炎因子IFN-γ、TNF-α和IL-6水平都显著低于模型组，谷维素组和辅酶Q10组血浆和空肠组织中抑炎因子IL-10显著高于模型组（P＜0.05）；辅酶Q10组血浆IgA的含量、谷维素组血浆IgG的含量、姜黄素组、谷维素组和辅酶Q10组IgM含量均显著高于模型组（P＜0.05）。以上结果表明，在本实验条件下，阿魏酸类似物都有抗应激、抗氧化能力以及提高免疫力的作用，且作用效果：阿魏酸＜姜黄素＜谷维素，其中谷维素作用接近于作为阳性对照的辅酶Q10，阿魏酸效果较差。

关键词：阿魏酸类似物应激氧化应激抗氧化免疫功能

For information in English, please click here

Effects of Ferulic Acid Analogs on Redox State and Immune Function in Stress Mice

LIU Ziwei ¹
刘子微（1994-），女，主要研究方向：食品营养与功能因子
ZHU Jianjin ¹
朱建津（1966-），男，副教授、硕导，主要研究方向：食品营养与功能因子
CHEN Weiwen ¹ LI Zhefeng ²

1、Food Science and Technology School,Jiangnan University,Wuxi Jiangsu,214122
2、Hangzhou King Technology Feed Co., Ltd., Hangzhou, Zhejiang, China, 311107)

Abstract： Experiments were conducted to evaluate the effects of ferulic acid and its analogs, curcumin and oryzanol, on the redox state and immune function in stress mice. Methods: Ninety male ICR mice were randomly divided into 6 groups: normal group, model group, ferulic acid group, curcumin group, oryzanol group and positive control (coenzyme Q10) group. Every 3 days, normal group was injected with normal saline, and other groups were injected with 40 mg/kg body weight of prednisone. The normal group and the model group were fed with normal feed. The other four groups were fed with 40 mg/kg of ferulic acid, curcumin, oryzanol, and coenzyme Q10. After 8 weeks of feeding, samples were sacrificed to determine the redox status and immune function related indicators of plasma, liver, heart, muscle and intestine. Results: (1) From the ninth day of modeling, the daily water intake of mice in the model group, ferulic acid group and curcumin group was significantly higher than that in the normal group. (P <0.05) (2) The contents of hypothalamic adrenergic hormone (CRH) and pituitary adrenocorticotropic hormone (ATCH) in ferulic acid, curcumin, oryzanol and coenzyme Q10 group were significantly lower than those in the model group (P <0.05); The content of plasma corticosterone (CROT) in oryzanol and coenzyme Q10 group was significantly lower than that in the model group (P <0.05). (3) Total antioxidant capacity (T-AOC) in heart, liver and muscle tissues of oryzanol group and coenzyme Q 10 group was significantly higher than that of model group (P <0.05); Total superoxide dismutase (SOD) activity in plasma, liver and muscle tissues of oryzanol and coenzyme Q 10 group was significantly higher than those in the model group (P <0.05); the levels of malondialdehyde (MDA) in the plasma and tissues of the oryzanol group and the coenzyme Q 10 group were significantly lower than those in the model group (P <0.05). 0.05). (4) The levels of proinflammatory factors IFN-γ, TNF-α, and IL-6 in the plasma and jejunum tissue of the curcumin group, oryzanol group and coenzyme Q10 group were significantly lower than those of the model group, and the intermediate inhibitory factor IL-10 in the plasma and jejunum tissue of oryzanol group and coenzyme Q10 group was significantly higher than that in the model group (P <0.05); the plasma IgA content of the coenzyme Q10 group, the plasma IgG content of the oryzanol group, and the IgM content of the curcumin group, oryzanol group and coenzyme Q10 group were significantly higher than the model group (P <0.05). The above results show that, under the conditions of this experiment, ferulic acid analogs have anti-stress, anti-oxidation ability and improve immunity, and sorting by effect difference: ferulic acid

Keywords： ferulic acid analogs stress oxidative stress antioxidant immune function

基金：

1. 国家自然科学基金（31700301）

论文图表：

引用

导出参考文献

.txt

.ris

.doc

刘子微，朱建津，陈巍文，等. 阿魏酸类似物对应激小鼠的氧化还原状态和免疫功能的影响[EB/OL]. 北京：中国科技论文在线 [2020-03-30]. https://www.paper.edu.cn/releasepaper/content/202003-328.

No.****

动态公开评议

共计0人参与

动态评论进行中

全部评论

0/1000

论文编号	202003-328
论文题目	阿魏酸类似物对应激小鼠的氧化还原状态和免疫功能的影响
文献类型
收录期刊	上传封面中文期刊英文期刊期刊名称（中文）期刊名称（英文）年，卷（）上传封面中文专著英文专著书名（中文）书名（英文）出版地出版社出版年上传封面中文译著英文译著书名（中文）书名（英文）出版地出版社出版年上传封面中文论文集英文论文集编者.论文集名称（中文） [c]. 出版地出版社出版年， - 编者.论文集名称（英文） [c]. 出版地出版社出版年，- 上传封面中文文献英文文献期刊名称（中文）期刊名称（英文）日期-- 在线地址http:// 上传封面中文文献英文文献文题（中文）文题（英文）出版地出版社,出版日期-- 上传封面中文文献英文文献文题（中文）文题（英文）出版地出版社,出版日期--
英文作者写法：中外文作者均姓前名后，姓大写，名的第一个字母大写，姓全称写出，名可只写第一个字母，其后不加实心圆点“.”, 作者之间用逗号“，”分隔，最后为实心圆点“.”, 示例1：原姓名写法：Albert Einstein,编入参考文献时写法：Einstein A. 示例2：原姓名写法：李时珍；编入参考文献时写法：LI S Z. 示例3：YELLAND R L,JONES S C,EASTON K S,et al.