A review: Inhibitors and activators for paraoxonase 1
首发时间:2020-04-28
Abstract:Paraoxonase 1 (PON1) is a calcium-dependent hydrolase with many physiological functions. The decrease of PON1 activity is related to many diseases. The research about PON1 is a hot topic, and its activators and inhibitors are expected to help in our diets and in choose of drugs. The papers about PON1 activators and inhibitors were collected and classified. The PON1 activators and inhibitors are grouped into four categories: in-vivo activators, in-vitro activators, in-vivo inhibitors and in-vitro inhibitors. For each activator or inhibitor, the activating effect or inhibiting effect along with the methods used was reviewed. Up to now, we found from literatures that there were 16 samples demonstrating activating effects on PON1 in-vivo and 5 compounds showed in-vitro activation. Of the 16 in-vivo activators there were 4 plant extracts and 12 pure components. Seven in-vivo inhibitors and 71 in-vitro inhibitors have been reported in publications. Additionally, smoking, drinking and treatment with exogenous gonadotropins induced decrease of PON1 activity. The summary of the activators and inhibitors are beneficial to reveal the structure-activity relationship, and also it provides convenience to look up the activating or inhibiting effects of the compounds on PON1 at a glance.
keywords: Paraoxonase 1 Activator inhibitor In vitro In vivo
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综述:对氧磷酶1的抑制剂和激动剂
摘要:对氧磷酶1(PON1)是一种具有多种生理功能的钙依赖性水解酶,其活性的下降与许多疾病有关。关于PON1的研究是一个热门话题,研究其激动剂和抑制剂对我们饮食和药物选择有所帮助。收集和分类有关PON1激动剂和抑制剂的论文。 PON1激动剂和抑制剂分为四类:体内激动剂,体外激动剂,体内抑制剂和体外抑制剂。对于每种激动剂或抑制剂,对其活化作用或抑制作用以及所用方法进行了综述。迄今为止,我们从文献中发现有16个样品证明了对PON1的体内活性有激动作用,还有5个化合物显示了体外激动作用。在16种体内激动剂中,有4种植物提取物和12种纯组分。在出版物中已经报道了七种体内抑制剂和71种体外抑制剂。此外,吸烟,饮酒和用外源促性腺激素治疗可导致PON1活性降低。激动剂和抑制剂的概述有益于揭示结构-活性关系,并且还提供了化合物对PON1的激动或抑制作用。
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综述:对氧磷酶1的抑制剂和激动剂
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