α-淀粉酶抑制剂（白芸豆提取物）对2型糖尿病患者生理代谢及肠道菌群的影响

赵建光; 张烽; 郁书怀; 杨瑞金; 赵伟

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α-淀粉酶抑制剂（白芸豆提取物）对2型糖尿病患者生理代谢及肠道菌群的影响

首发时间：2020-06-28

赵建光 ^{1
2}
赵建光（1981-），男，硕士研究生。
张烽 ³ 郁书怀 ^{1
2} 杨瑞金 ^{1
2} 赵伟 ^{1
2}
赵伟（1982-），男，教授，博导，主要研究方向：食品加工与配料

1、江南大学国家重点实验室，无锡，21400
2、江南大学食品学院，无锡，214000
3、江南大学附属医院无锡中西医结合研究所，无锡，214000

摘要：本研究在2型糖尿病患者的膳食营养干预中引入白芸豆淀粉酶抑制剂（α-AI），研究其对2型糖尿病生理代谢指标及肠道菌群的影响，为糖尿病的营养干预提供更简便、有效的方案。对2型糖尿病患者的膳食营养干预，引入白芸豆α-AI提取物，并辅以糖尿病膳食宣教、血糖监测等综合干预手段，研究其对2型糖尿病生理代谢指标的影响，并通过研究其肠道菌群的变化，揭示白芸豆α-AI提取物在体内改善糖代谢的机理。结果显示，患者经白芸豆α-AI提取物干预后，血糖控制良好，糖化血红蛋白(HbA1c)、空腹血糖和餐后血糖显著降低。低密度脂蛋白（LDL-c）下降幅度显著大于对照组，高密度脂蛋白（HDL-c）升高幅度显著大于对照组。服用白芸豆α-AI提取物对患者糖尿病并发症亦有改善作用。白芸豆提取物通过减少消化系统对淀粉的吸收，使更多淀粉到达大肠，在干预2个月时调节肠道菌群结构的能力最强，而到4个月时调节作用减弱。干预前后，菌群的α-多样性均未发生显著变化，菌群β-多样性与对照组相比均存在着显著差异（干预2个月时，p<0.05；干预4个月时，p<0.01）。白芸豆提取物能在干预2个月时显著富集Bifidobacterium、Faecalibacterium等富含有益菌的菌属，降低Escherichia/Shigella这一般被认为含有潜在机会致病菌的菌属的丰度，而到4个月时，仅显著富集Bifidobacterium菌属。因此，白芸豆α-AI提取物对糖尿病人血糖的调节，除了其直接的降低淀粉的吸收外，还有可能通过改变肠道菌群的结构起作用。

关键词： 2型糖尿病 α-淀粉酶抑制剂糖代谢脂代谢肠道菌群

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The effect of α - amylase inhibitor (white kidney bean extract) on the physiological metabolism and intestinal flora of type 2 diabetes mellitus patients

ZHAO Jianguang ^{1
2}
赵建光（1981-），男，硕士研究生。
ZHANG Feng ³ YU Shuhuai ^{1
2} YANG Ruijin ^{1
2} ZHAO Wei ^{1
2}
赵伟（1982-），男，教授，博导，主要研究方向：食品加工与配料

1、State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214000
2、School of Food Science and Technology, Jiangnan University, Wuxi, 214000
3、Wuxi Institute of Integrated Traditional Chinese and Westren Medicine, Affiliated Hospital of Jiangnan University, Wuxi, 214000

Abstract：Based on diabetes diet education, blood glucose monitoring and other comprehensive intervention, the α-AI extract of white kidney bean was added to dietary of type 2 diabetes patients. Its effect on the physiological and metabolic indicators of type 2 diabetes were studied, and the mechanism of white kidney bean α-ai extract in vivo by studying the changes of its intestinal flora have been reaveled.The results showed that the blood glucose was well controlled after the intervention of white kidney bean α-AI extract, and the glycosylated hemoglobin (HbA1c), fasting blood glucose and postprandial blood glucose were significantly decreased. The decrease of low-density lipoprotein (LDL-c) was significantly larger than that of the control group, on the contrary, the increase of high-density lipoprotein (HDL-c) was significantly larger than that of the control group. The diabetic complications also were improved after eating white kidney bean α-AI extract. After eating white kidney bean extract, the absorption of starch in the digestive system was reduced, so that more starch to the large intestine. Compared to 4 months intervention, the change of structure of intestinal flora was more significant foe 2 months intervention. The α- diversity of flora did not change significantly before and after intervention, and the diversity β- flora was significantly different compared with the control (2 months of intervention ,4 months of p<0.05; intervention, p<0.01). After adding white kidney bean extract 2 months, Bifidobacterium, Faecalibacterium and other beneficial bacteria wrere significantly enriched, and the abundance of Escherichia / Shigella, which is generally considered to contain potential opportunistic bacteria, were reduced. However, only Bifidobacterium was significantly enriched at 4 months. .

Keywords： α-Amylase inhibitor type 2 diabetickey Glycometabolism Lipid metabolism Intestinal flora

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赵建光，张烽，郁书怀，等. α-淀粉酶抑制剂（白芸豆提取物）对2型糖尿病患者生理代谢及肠道菌群的影响[EB/OL]. 北京：中国科技论文在线 [2020-06-28]. https://www.paper.edu.cn/releasepaper/content/202006-151.

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论文编号	202006-151
论文题目	α-淀粉酶抑制剂（白芸豆提取物）对2型糖尿病患者生理代谢及肠道菌群的影响
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