基于钾离子通道"折纸风车"模型的启发性观点
首发时间:2020-06-29
摘要:应用K+通道"折纸风车"模型原理,合理阐释了神经纤维细胞与心肌细胞动作电位发生全过程,其核心观点:细胞动作电位下降相,由K+内流所主导,与传统理论--离子学说的核心观点背道而驰。离子学说认为,细胞动作电位下降相,由K+外流所主导。 面对如此截然相反的两种观点,作者追根溯源,对细胞生物电产生机制的基础理论研究与经典基础实验结果进行了梳理,并由此产生了一系列启发性观点:1、离子学说存在先天性不足;2、GHK方程与H-H方程存在原则性缺陷;3、离子通道可能"同向共享";4、钠-钾泵、钙泵等可能不存在。 本文观点可证伪。如果能够证明"细胞动作电位下降相,由K+外流所主导",本文的所有观点都将是不成立的。反之,本文的系列启发性观点将会不可避免地引发生命科学领域的一场革命,不但与人类重大疾病的发病原因、治疗原则与方法密切相关,而且还可能深刻地影响到生命科学领域科研人员今后的科研方向。 因此作者建议,生命科学领域学者应对现有生物电知识体系进行再梳理--去伪存真、正本清源,特别要重点关注Hodgkin和Huxley在1952年发表的论文。同时,还要对膜学说、离子学说以及GHK方程、H-H方程的科学性与科学价值重新做出评价,有必要基于Bernstein膜学说提出新的学说和建立细胞动作电位新的数学模型。
关键词: 细胞生物学 K+通道"折纸风车"模型 动作电位 钠-钾泵 离子学说 GHK方程 H-H方程
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Enlightening Point of View Based on Potassium Channel "Origami Windmill" Model
Abstract:IApplying the K+ channel origami windmill model principle, the whole process of action potential generation of nerve fiber cells and cardiomyocytes is explained reasonably. Its core view is: cell action potential decline phase, dominated by influx of potassium ions. This is contrary to the core idea of the traditional theory-ionic theory. According to ionic theory, cell action potential decline phase, dominated by outflow of K+ ions. In the face of such two opposing views, the author traces back to the source, combing on the basic theoretical research on the production mechanism of cell bioelectricity generation and the results of classical basic experiments. And a series of enlightening viewpoints are produced:1. Ionic theory has its preexistence deficiency; 2. There are principle defects in GHK equation and H-H equation; 3. Ion channels may "same direction sharing"; 4. Sodium-potassium pumps, calcium pumps and so on May not exist. The thesis\'s Point is falsifiable. If "cell action potential decline stage, dominated by outflow of K+ ions" can be proved, all the points in this paper will not be true. On the contrary, the series of enlightening views in this paper will inevitably lead to a revolution in the field of life science. The viewpoint of this paper is not only closely related to the causes of human major diseases, treatment principles and methods, but also may have a profound impact on the future research direction of life science researchers. So the author suggests that scholars in the field of life science should re sort out the existing bioelectricity knowledge system-eliminate the false, save the true and clear the source, especially focusing on the papers published by Hodgkin and Huxley in 1952; At the same time, it is necessary to reevaluate the scientificity and scientific value of membrane theory, ionic theory, GHK equation and H-H equation, and put forward new theories based on Bernstein membrane theory, and establishing a new mathematical model of cell action potential.
Keywords: Cell biology K+ channel "origami windmill" model action potential sodium-potassium pump ionic theory GHK equation H-H equation
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