Principle of K+ channel "Origami windmill" model and the phenomenon of cell bioelectricity

• 1、Ya’ou Brain Science Institute of Heilongjiang province, Harbin 150090

Abstract：The K+ channel "origami windmill" model proposed in this paper, with a structure such as the "origami windmill" model, is an independent functional unit. The four channels spiral synchronously and rotate in one direction, and the K+ transport mode is passive and one-way, without ATP dependence, which is different from the previous "paddle", "propeller" and "revolving door" models.The mechanism of action is that the repulsive force formed by K+ and positively charged amino acids in the spiral of the channel pushes the "wind teeth" back and the "windmill" rotates, while the size of the aperture of K+ channel changes with the speed of the "windmill" and determines the "opening" and "closing" of the channel hole.Based on the K+ channel "origami windmill" model, it can be inferred that there are at least two types of channels on the cell membrane,one type of channel is the entrance E channel, such as the "origami windmill" model, at least one E channel per cell;The other type of channel is exit L channel, whose structure only transforms between "open" and "closed" conformations. it is a passive unidirectional channel with more than one L channel per cell.With respect to K+, the pore diameter of the two channels is greater than or equal to K+ diameter in "open" and smaller than K+ diameter in "close", while the pore diameter is smaller than K+ diameter but not smaller than Na+ diameter in "close". All ions or molecules entering and leaving the cell comply with the principle of"same direction sharing". The generation mechanism of action potential of nerve fiber cells and ventricular myocytes was explained reasonably by applying the principle of K+ channel "origami windmill" model, further proveding "origami windmill" the model theory, "the theory ofdove-like particles""the theory of braincell activation" of science, also proved that the viewpoint of "action potential descending phase, dominated by K+ internal current" is correct.The "origami windmill" model, which USES the biophysical principles of cells to reveal the operation mechanism of K+ channel, has implications for other basic research related to it, and may help to answer the basic biological questions of human health and disease from the source.

Keywords： K+ channel "origami windmill" model Resting potential action potential Sodium-potassium pump